Elston J S
National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
J Neurol. 1992 Jan;239(1):5-8. doi: 10.1007/BF00839203.
The aetiology of blepharospasm and hemifacial spasm is different, but both produce involuntary eye closure and facial movements which do not respond to systemic drug treatment. The introduction of therapeutic focal muscle weakening with botulinum toxin injections in the early 1980s appeared to offer great promise in the management of these conditions. In this paper the results of botulinum toxin treatment of 234 patients with blepharospasm and 73 patients with hemifacial spasm over a 7-year period have been analysed. Most patients receive sustained benefit from repeated injections whilst side-effects become less frequent. A clinically recognisable subgroup of patients with blepharospasm respond poorly and may be better treated surgically.
眼睑痉挛和半面痉挛的病因不同，但都会导致无法自主控制的闭眼和面部运动，且对全身性药物治疗无反应。20世纪80年代初引入的肉毒杆菌毒素注射治疗性局部肌肉松弛，似乎为这些病症的治疗带来了很大希望。本文分析了7年间234例眼睑痉挛患者和73例半面痉挛患者接受肉毒杆菌毒素治疗的结果。大多数患者通过反复注射持续受益，同时副作用的发生频率降低。临床上可识别的一部分眼睑痉挛患者对治疗反应不佳，手术治疗可能效果更好。
