Sterling Richard K
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA.
Clin Infect Dis. 2005 Apr 15;40 Suppl 5:S270-5. doi: 10.1086/427439.
Hepatitis C virus (HCV) coinfection is common in patients infected with human immunodeficiency virus (HIV), because the viruses share common routes of transmission. With the marked increase in life expectancy of HIV-infected patients associated with the use of highly active antiretroviral therapy, HCV infection has become a significant cause of morbidity and mortality in coinfected patients. As a result, there has been increasing attention to adequate assessment of HCV infection during the last several years. Unlike liver enzymes and HCV RNA levels, which can fluctuate widely and do not correlate with the severity of disease, liver biopsy has become the cornerstone in the evaluation of chronic HCV infection. However, there remain important questions and controversies related to adequately determining the histological severity of liver disease and the role of liver biopsy in HIV-HCV-coinfected patients.
丙型肝炎病毒（HCV）合并感染在感染人类免疫缺陷病毒（HIV）的患者中很常见，因为这两种病毒有共同的传播途径。随着使用高效抗逆转录病毒疗法使HIV感染患者的预期寿命显著延长，HCV感染已成为合并感染患者发病和死亡的重要原因。因此，在过去几年中，对HCV感染进行充分评估的关注度日益增加。与肝酶和HCV RNA水平不同，肝酶和HCV RNA水平可能波动很大且与疾病严重程度无关，肝活检已成为评估慢性HCV感染的基石。然而，在充分确定肝脏疾病的组织学严重程度以及肝活检在HIV-HCV合并感染患者中的作用方面，仍存在重要问题和争议。
