Beneduci Amerigo, Chidichimo Giuseppe, De Rose Renata, Filippelli Luigi, Straface Serafina V, Venuta S
Department of Chemistry, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.
Anticancer Res. 2005 Mar-Apr;25(2A):1023-8.
The biological effects produced by low power millimeter waves (MMW) were studied on the RPMI 7932 human melanoma cell line. Three different frequency-type irradiation modes were used: the 53.57-78.33 GHz wide-band frequency range, the 51.05 GHz and the 65.00 GHz monochromatic frequencies. In all three irradiation conditions, the radiation energy was low enough not to increase the temperature of the cellular samples. Three hours of radiation treatment, applied every day to the melanoma cell samples, were performed at each frequency exposure condition. The wide-band irradiation treatment effectively inhibited cell growth, while both the monochromatic irradiation treatments did not affect the growth trend of RPMI 7932 cells. A light microscopy analysis revealed that the low-intensity wide-band millimeter radiation induced significant morphological alterations on these cells. Furthermore, a histochemical study revealed the low proliferative state of the irradiated cells. This work provides further evidence of the antiproliferative effects on tumor cells induced by low power MMW in the 50-80 GHz frequency range of the electromagnetic spectrum.
在RPMI 7932人黑色素瘤细胞系上研究了低功率毫米波（MMW）产生的生物学效应。使用了三种不同的频率类型照射模式：53.57 - 78.33 GHz宽带频率范围、51.05 GHz和65.00 GHz单色频率。在所有三种照射条件下，辐射能量都足够低，不会提高细胞样品的温度。在每个频率暴露条件下，每天对黑色素瘤细胞样品进行三小时的辐射处理。宽带照射处理有效地抑制了细胞生长，而两种单色照射处理均未影响RPMI 7932细胞的生长趋势。光学显微镜分析显示，低强度宽带毫米波辐射对这些细胞诱导了显著的形态学改变。此外，组织化学研究揭示了受照射细胞的低增殖状态。这项工作进一步证明了在电磁频谱50 - 80 GHz频率范围内，低功率毫米波对肿瘤细胞具有抗增殖作用。
