Bellucci Roberto, Scialdone Antonio, Buratto Lucio, Morselli Simonetta, Chierego Chiara, Criscuoli Alessandra, Moretti Giuseppe, Piers Patricia
Ophthalmic Unit, Hospital and University of Verona, Verona, Italy.
J Cataract Refract Surg. 2005 Apr;31(4):712-7. doi: 10.1016/j.jcrs.2004.08.049.
To evaluate best corrected visual acuity (BCVA) and photopic and mesopic contrast sensitivity in pseudophakic patients implanted either with the aspheric intraocular lens (IOL) designed to correct for corneal spherical aberration or with a conventional IOL.
Three surgical centers participated this prospective randomized masked comparative study.
Thirty eyes of 30 patients after aspheric lens implantation (Pfizer/Pharmacia Tecnis Z9000) were compared with 30 eyes of 30 age-matched patients after conventional lens implantation (Alcon AcrySof SA60AT). Two to three months after surgery, best spectacle corrected distance visual acuity was measured using the Early Treatment Diabetic Retinopathy Study chart. Contrast sensitivity was measured by sinusoidal grating charts for distance at photopic (85 cd/m(2)) and mesopic (6 cd/m(2)) luminance level with optical correction in place. Tested spatial frequencies were 1.5, 3, 6, 12, and 18 cycles per degree (cpd).
The mean BCVA was -0.053 +/- 0.044 logMAR in eyes with the aspheric Tecnis IOL and 0.006 +/- 0.059 logMAR in eyes with the conventional AcrySof IOL (P=.0001). Eyes with the aspheric IOL showed better contrast sensitivity at spatial frequencies of 3 cpd (P<.05) and 6, 12, and 18 cpd (P<.01) in photopic and in mesopic conditions. Peak improvement occurred at 18 cpd and was 36% (0.29 log units) in photopic and 54% (0.27 log units) in mesopic conditions.
The aspheric Tecnis IOL yielded better BCVA and better distance contrast sensitivity than the conventional IOL. The differences were clinically significant for higher spatial frequencies. The results give some suggestions for further studies.
评估植入用于矫正角膜球差的非球面人工晶状体（IOL）或传统IOL的人工晶状体眼的最佳矫正视力（BCVA）以及明视觉和 mesopic 对比敏感度。
三个手术中心参与了这项前瞻性随机双盲对照比较研究。
将30例患者植入非球面晶状体（辉瑞/法玛西亚Tecnis Z9000）后的30只眼与30例年龄匹配的患者植入传统晶状体（爱尔康AcrySof SA60AT）后的30只眼进行比较。术后两到三个月，使用早期糖尿病性视网膜病变研究图表测量最佳眼镜矫正远视力。在明视觉（85 cd/m²）和 mesopic（6 cd/m²）亮度水平下，使用正弦光栅图表在有光学矫正的情况下测量距离对比敏感度。测试的空间频率为每度1.5、3、6、12和18周/度（cpd）。
非球面Tecnis IOL眼的平均BCVA为-0.053±0.044 logMAR，传统AcrySof IOL眼的平均BCVA为0.006±0.059 logMAR（P = 0.0001）。非球面IOL眼在明视觉和mesopic条件下，在3 cpd（P < 0.05）以及6、12和18 cpd（P < 0.01）的空间频率下显示出更好的对比敏感度。峰值改善出现在18 cpd，在明视觉条件下为36%（0.29对数单位），在mesopic条件下为54%（0.27对数单位）。
非球面Tecnis IOL比传统IOL产生更好的BCVA和更好的距离对比敏感度。对于更高的空间频率，差异具有临床意义。结果为进一步研究提供了一些建议。
