血液中分离出的酵母菌株对氟康唑和两性霉素B的体外敏感性。
In vitro susceptibility of yeast isolates from the blood to fluconazole and amphotericin B.
作者信息
Dermoumi H
机构信息
Institute of Medical Microbiology, University of Essen, FRG.
出版信息
Chemotherapy. 1992;38(2):112-7. doi: 10.1159/000238950.
221 yeast strains including 131 of Candida albicans, 21 of C. tropicals, 23 of C. parapsilosis, 19 of C. glabrata, 7 of C. guilliermondii, 6 of C. krusei and of other species were isolated from the blood. The activity of fluconazole and amphotericin B was investigated by means of a photometer-read broth microdilution method measuring the 30% inhibitory concentrations (IC30). The results of fluconazole showed a higher susceptibility of C. albicans compared to the other species. However, 6 (4.5%) resistant strains of C. albicans were found. Low sensitivity and resistance were evaluated for C. krusei and C. glabrata strains. All isolates showed susceptibility to amphotericin B.
从血液中分离出221株酵母菌株，其中白色念珠菌131株、热带念珠菌21株、近平滑念珠菌23株、光滑念珠菌19株、季也蒙念珠菌7株、克柔念珠菌6株以及其他菌种。采用光度计读取的肉汤微量稀释法测定30%抑制浓度（IC30），研究氟康唑和两性霉素B的活性。氟康唑的结果显示，与其他菌种相比，白色念珠菌的敏感性更高。然而，发现了6株（4.5%）白色念珠菌耐药菌株。对克柔念珠菌和光滑念珠菌菌株评估了低敏感性和耐药性。所有分离株对两性霉素B均敏感。
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