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Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and candida infections. Subcommittee on Antifungal Susceptibility Testing of the National Committee for Clinical Laboratory Standards.抗真菌药敏试验解释性断点的制定：氟康唑、伊曲康唑和念珠菌感染的体外-体内相关性数据的概念框架与分析。美国国家临床实验室标准委员会抗真菌药敏试验小组委员会
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Comparative evaluation of macrodilution and chromogenic agar screening for determining fluconazole susceptibility of Candida albicans.用于测定白色念珠菌氟康唑敏感性的常量稀释法和显色琼脂筛选法的比较评估
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Electrophoretic karyotype and in vitro antifungal susceptibility of Cryptococcus neoformans isolates from AIDS patients.艾滋病患者新型隐球菌分离株的电泳核型及体外抗真菌药敏性
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Molecular subtypes and antifungal susceptibilities of serial Cryptococcus neoformans isolates in human immunodeficiency virus-associated Cryptococcosis. Cryptococcal Disease Active Surveillance Group.人类免疫缺陷病毒相关隐球菌病中新型隐球菌系列分离株的分子亚型及抗真菌药敏性。隐球菌病主动监测小组
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Editorial response: management of cryptococcal meningitis--have we answered all the questions?编辑回应：隐球菌性脑膜炎的管理——我们是否回答了所有问题？
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Identification of patients with acute AIDS-associated cryptococcal meningitis who can be effectively treated with fluconazole: the role of antifungal susceptibility testing.可通过氟康唑有效治疗的急性艾滋病相关隐球菌性脑膜炎患者的识别：抗真菌药敏试验的作用
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Simple method for detecting fluconazole-resistant yeasts with chromogenic agar.用显色琼脂检测氟康唑耐药酵母的简易方法。
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Multicenter evaluation of a broth macrodilution antifungal susceptibility test for yeasts.酵母肉汤大稀释法抗真菌药敏试验的多中心评估
Antimicrob Agents Chemother. 1993 Jan;37(1):39-45. doi: 10.1128/AAC.37.1.39.

美国国家临床实验室标准委员会肉汤大稀释法和琼脂稀释法对新型隐球菌氟康唑敏感性检测的比较评估

Comparative evaluation of National Committee for Clinical Laboratory Standards broth macrodilution and agar dilution screening methods for testing fluconazole susceptibility of Cryptococcus neoformans.

作者信息

Kirkpatrick W R, McAtee R K, Revankar S G, Fothergill A W, McCarthy D I, Rinaldi M G, Patterson T F

机构信息

Department of Medicine, University of Texas Health Science Center at San Antonio, 78284-7881, USA.

出版信息

J Clin Microbiol. 1998 May;36(5):1330-2. doi: 10.1128/JCM.36.5.1330-1332.1998.

DOI:10.1128/JCM.36.5.1330-1332.1998
PMID:9574699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC104822/
Abstract

A simple screening method for fluconazole susceptibility of Cryptococcus neoformans using 2% dextrose Sabouraud dextrose agar (SabDex) with fluconazole was compared to the National Committee for Clinical Laboratory Standards (NCCLS) broth macrodilution method. By this method, fluconazole-susceptible C. neoformans isolates are significantly smaller on medium with fluconazole than on fluconazole-free medium. Isolates with decreased susceptibility have normal-size colonies on medium containing fluconazole. The 48-h NCCLS broth macrodilution MICs (NCCLS MICs) for isolates with normal-size colonies on 8- or 16-microg/ml fluconazole plates were predicted to be > or =8 or > or =16 microg/ml, respectively. On medium with 16 microg of fluconazole per ml, all strains (84 of 84) for which the NCCLS MICs were <16 microg/ml were correctly predicted, as were all isolates (7 of 7) for which the MICs were > or =16 microg/ml. Agar dilution appears to be an effective screening method for fluconazole resistance in C. neoformans.

摘要

使用含氟康唑的2%葡萄糖沙氏葡萄糖琼脂（SabDex）对新型隐球菌的氟康唑敏感性进行简单筛选方法，并与美国国家临床实验室标准委员会（NCCLS）肉汤稀释法进行比较。通过这种方法，对氟康唑敏感的新型隐球菌分离株在含氟康唑的培养基上比在不含氟康唑的培养基上明显更小。敏感性降低的分离株在含氟康唑的培养基上具有正常大小的菌落。在8或16μg/ml氟康唑平板上具有正常大小菌落的分离株的48小时NCCLS肉汤稀释MIC（NCCLS MIC）预计分别>或 =8或>或 =16μg/ml。在每毫升含16μg氟康唑的培养基上，所有NCCLS MIC<16μg/ml的菌株（84株中的84株）以及所有MIC>或 =16μg/ml的分离株（7株中的7株）均被正确预测。琼脂稀释法似乎是一种有效的新型隐球菌氟康唑耐药性筛选方法。