从苹果中分离出的原花青素三聚体至五聚体可抑制B16小鼠黑色素瘤细胞中的黑色素生成。
Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells.
作者信息
Shoji Toshihiko, Masumoto Saeko, Moriichi Nina, Kobori Masuko, Kanda Tomomasa, Shinmoto Hiroshi, Tsushida Tojiro
机构信息
Fundamental Research Laboratory, Asahi Breweries, Ltd., 1-21 Midori 1-chome, Moriya, Ibaraki 302-0106, Japan.
出版信息
J Agric Food Chem. 2005 Jul 27;53(15):6105-11. doi: 10.1021/jf050418m.
The effects of apple polyphenols on melanogenesis in B16 mouse melanoma cells were investigated. The inhibitory effect of apple polyphenols was stronger than that of arbutin or kojic acid. Three polyphenol fractions (phenolic acid derivatives, procyanidins and other flavonoids) were isolated, and the procyanidins were fractionated according to the degree of polymerization using normal-phase chromatography. The procyanidin trimer-to-pentamer fractions were found to have the most pronounced effect on melanogenesis. Furthermore, each procyanidin fraction inhibited mushroom tyrosinase. No correlation between the degree of procyanidin polymerization and tyrosinase inhibitory activity was observed. Nevertheless, these observations suggest that procyanidins are effective inhibitors of tyrosinase.
研究了苹果多酚对B16小鼠黑色素瘤细胞黑色素生成的影响。苹果多酚的抑制作用强于熊果苷或曲酸。分离出三种多酚组分（酚酸衍生物、原花青素和其他类黄酮），并使用正相色谱法根据聚合度对原花青素进行分级。发现原花青素三聚体至五聚体组分对黑色素生成的影响最为显著。此外，每个原花青素组分均抑制蘑菇酪氨酸酶。未观察到原花青素聚合度与酪氨酸酶抑制活性之间的相关性。然而，这些观察结果表明原花青素是酪氨酸酶的有效抑制剂。
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