中东脑炎患者脑脊液中单纯疱疹病毒（1型和2型）、水痘-带状疱疹病毒、巨细胞病毒以及人类疱疹病毒6型和7型DNA的流行情况
Prevalence of herpes simplex virus (types 1 and 2), varicella-zoster virus, cytomegalovirus, and human herpesvirus 6 and 7 DNA in cerebrospinal fluid of Middle Eastern patients with encephalitis.
作者信息
Ibrahim Ali I, Obeid Michel T, Jouma Muhidien J, Roemer Klaus, Mueller-Lantzsch Nikolaus, Gärtner Barbara C
机构信息
Department of Clinical Chemistry and Microbiology, University of Damascus, Syria.
出版信息
J Clin Microbiol. 2005 Aug;43(8):4172-4. doi: 10.1128/JCM.43.8.4172-4174.2005.
Abstract
HSV-1 DNA was detected in 32 (30%) of 106 cerebrospinal fluid samples from patients with encephalitis. Cytomegalovirus, varicella-zoster virus, and human herpesvirus 6 (HHV-6) DNAs were each detected in three patients (3%); herpes simplex virus type 2 (HSV-2) and HHV-7 PCRs were negative. HSV detection was associated with seizure (P = 0.02), especially focal seizure (P = 0.0002), and pathological computed tomography (P = 0.02) with focal lesions (P = 0.0004).
摘要
在106例脑炎患者的脑脊液样本中，32例（30%）检测到单纯疱疹病毒1型（HSV-1）DNA。巨细胞病毒、水痘-带状疱疹病毒和人类疱疹病毒6型（HHV-6）DNA在3例患者（3%）中均被检测到；2型单纯疱疹病毒（HSV-2）和HHV-7的聚合酶链反应（PCR）结果为阴性。HSV检测与癫痫发作相关（P = 0.02），尤其是局灶性癫痫发作（P = 0.0002），以及与有局灶性病变的病理计算机断层扫描（P = 0.02）相关（P = 0.0004）。
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