George K, Willingham V, Cucinotta F A
Wyle Laboratories, Houston, Texas 77058, USA.
Radiat Res. 2005 Oct;164(4 Pt 2):474-80. doi: 10.1667/rr3323.1.
Follow-up measurements of chromosome aberrations in the blood lymphocytes of astronauts were performed by FISH chromosome painting at various intervals from 5 months to more than 5 years after space flight and compared to preflight baseline measurements. For five of the six astronauts studied, the analysis of individual time courses for translocations revealed a temporal decline of yields with half-lives ranging from 10 to 58 months. The yield of exchanges remained unchanged for the sixth astronaut during an observation period of 5 months after flight. These results may indicate complications with the use of stable aberrations for retrospective dose reconstruction, and the differences in the decay time may reflect individual variability in risk from space radiation exposure.
通过荧光原位杂交染色体涂染技术，对宇航员血液淋巴细胞中的染色体畸变进行了后续测量，测量时间为太空飞行后5个月至5年多的不同时间间隔，并与飞行前的基线测量结果进行了比较。在研究的6名宇航员中，有5名宇航员的易位个体时间进程分析显示，产量随时间下降，半衰期为10至58个月。在飞行后的5个月观察期内，第六名宇航员的交换产量保持不变。这些结果可能表明，在使用稳定畸变进行回顾性剂量重建时存在并发症，衰变时间的差异可能反映了太空辐射暴露风险的个体差异。
