Villaseñor Irene M, Lamadrid Mary Rose A
Natural Products Research Laboratory, Institute of Chemistry, University of the Philippines, Diliman, Quezon City 1101, Philippines.
J Ethnopharmacol. 2006 Mar 8;104(1-2):129-31. doi: 10.1016/j.jep.2005.08.067. Epub 2005 Oct 25.
Validation of the ethnobotanical use of the leaves of Artemisia vulgaris Linn. (Compositae), Eucalyptus tereticornis Sm. (Myrtaceae), Solanum nigrum Linn. (Solanaceae), and Vitex negundo Linn. (Verbenaceae); stems of Nopalea cochinellifera (Linn.) Salm-Dyck (Cactaceae); roots of Imperata cylindrica Beauv. (Gramineae); dried bark of Syzygium cumini (Linn.) Skeels (Myrtaceae) as anti-diabetic agents using the oral glucose tolerance test showed that only the bark of Syzygium cumini and the leaves of Vitex negundo and Eucalyptus tereticornis exhibited anti-hyperglycemic activities when fed simultaneously with glucose. At the same dosages of 5 mg/20 g mouse, Syzygium cumini-treated mice showed a significant decrease in blood glucose levels (BGLs) at 30 min (alpha=0.10) and from 45 min onwards at alpha=0.05. Vitex negundo exhibited greater anti-hyperglycemic activity than Eucalyptus tereticornis. Both showed a significant decrease in BGLs at 60 min but at alpha=0.05 for Vitex negundo and at alpha=0.07 for Eucalyptus tereticornis. There was no significant lowering in BGLs for Imperata cylindrica and Solanum nigrum while there was even an increase in BGLs for Nopalea cochinellifera and Artemisia vulgaris.
通过口服葡萄糖耐量试验验证普通蒿（菊科）、圆锥花桉（桃金娘科）、龙葵（茄科）和黄荆（马鞭草科）叶子；胭脂仙人掌（仙人掌科）茎；白茅（禾本科）根；以及乌墨（桃金娘科）干树皮作为抗糖尿病药物的民族植物学用途，结果显示，仅乌墨树皮、黄荆叶和圆锥花桉叶在与葡萄糖同时喂食时表现出降血糖活性。在5毫克/20克小鼠的相同剂量下，乌墨处理的小鼠在30分钟时血糖水平（BGLs）显著降低（α = 0.10），从45分钟起在α = 0.05时显著降低。黄荆比圆锥花桉表现出更强的降血糖活性。两者在60分钟时BGLs均显著降低，但黄荆在α = 0.05时，圆锥花桉在α = 0.07时。白茅和龙葵的BGLs没有显著降低，而胭脂仙人掌和普通蒿的BGLs甚至有所升高。
