蒙古族人群10个X染色体短串联重复序列基因座的遗传多态性模式
Patterns of genetic polymorphism at the 10 X-chromosome STR loci in Mongol population.
作者信息
Liu Qingbo, Li Shengbin
机构信息
Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an Shaanxi 710061, China.
出版信息
Forensic Sci Int. 2006 Apr 20;158(1):76-9. doi: 10.1016/j.forsciint.2005.04.027. Epub 2005 Nov 8.
Genetic diversity at 10 X-chromosome STR loci has been approved and widely used for forensic science field. In this paper, we have studied this genetic diversity in various Mongol ethnic group with geographic backgrounds. Allele frequencies of 10 X-chromosome STR loci, including DXS7133, DXS6799, DXS8378, DXS7423, DXS6804, HPRTB, DXS7424, DXS7132, DXS6789 and DXS101, were obtained from healthy unrelated individuals (53 females and 47 males) of Mongol ethnic group lived in north China. Gene diversity analysis showed that the average heterozygosity was uniformly high (0.687) in the studied population. The coefficient of PIC was 0.99998.
10个X染色体STR基因座的遗传多样性已得到认可并在法医学领域广泛应用。在本文中，我们研究了不同地理背景的蒙古族群体中的这种遗传多样性。从生活在中国北方的蒙古族健康无关个体（53名女性和47名男性）中获得了10个X染色体STR基因座（包括DXS7133、DXS6799、DXS8378、DXS7423、DXS6804、HPRTB、DXS7424、DXS7132、DXS6789和DXS101）的等位基因频率。基因多样性分析表明，所研究群体的平均杂合度普遍较高（0.687）。PIC系数为0.99998。
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