电子传递蛋白之间水相隧道通路的性质。
The nature of aqueous tunneling pathways between electron-transfer proteins.
作者信息
Lin Jianping, Balabin Ilya A, Beratan David N
机构信息
Departments of Chemistry and Biochemistry, Duke University, Durham, NC 27708, USA.
出版信息
Science. 2005 Nov 25;310(5752):1311-3. doi: 10.1126/science.1118316.
Abstract
Structured water molecules near redox cofactors were found recently to accelerate electron-transfer (ET) kinetics in several systems. Theoretical study of interprotein electron transfer across an aqueous interface reveals three distinctive electronic coupling mechanisms that we describe here: (i) a protein-mediated regime when the two proteins are in van der Waals contact; (ii) a structured water-mediated regime featuring anomalously weak distance decay at relatively close protein-protein contact distances; and (iii) a bulk water-mediated regime at large distances. Our analysis explains a range of otherwise puzzling biological ET kinetic data and provides a framework for including explicit water-mediated tunneling effects on ET kinetics.
摘要
最近发现，氧化还原辅因子附近的结构化水分子在几个系统中加速了电子转移（ET）动力学。跨水界面的蛋白质间电子转移的理论研究揭示了三种独特的电子耦合机制，我们在此进行描述：（i）当两种蛋白质处于范德华接触时的蛋白质介导机制；（ii）在相对较近的蛋白质-蛋白质接触距离处具有异常弱的距离衰减特征的结构化水介导机制；以及（iii）在远距离处的大量水介导机制。我们的分析解释了一系列原本令人困惑的生物ET动力学数据，并提供了一个框架，用于纳入对ET动力学的明确水介导隧穿效应。
相似文献
1
The nature of aqueous tunneling pathways between electron-transfer proteins.电子传递蛋白之间水相隧道通路的性质。
Science. 2005 Nov 25;310(5752):1311-3. doi: 10.1126/science.1118316.
2
Interprotein electron transfer from cytochrome c2 to photosynthetic reaction center: tunneling across an aqueous interface.从细胞色素c2到光合反应中心的蛋白间电子转移：跨越水相界面的隧穿效应
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3558-63. doi: 10.1073/pnas.0409600102. Epub 2005 Feb 28.
3
Protein electron transfer rates set by the bridging secondary and tertiary structure.由桥接二级和三级结构设定的蛋白质电子转移速率。
Science. 1991 May 31;252(5010):1285-8. doi: 10.1126/science.1656523.
4
Interfacial hydration, dynamics and electron transfer: multi-scale ET modeling of the transient [myoglobin, cytochrome b5] complex.界面水合作用、动力学和电子转移：瞬态 [肌红蛋白、细胞色素 b5] 配合物的多尺度 ET 建模。
Phys Chem Chem Phys. 2012 Oct 28;14(40):13881-9. doi: 10.1039/c2cp41949a. Epub 2012 Sep 7.
5
Prediction of reorganization free energies for biological electron transfer: a comparative study of Ru-modified cytochromes and a 4-helix bundle protein.预测生物电子转移的无重组自由能：Ru 修饰细胞色素和 4 螺旋束蛋白的比较研究。
J Am Chem Soc. 2010 Dec 1;132(47):17032-40. doi: 10.1021/ja107876p. Epub 2010 Nov 5.
6
Steering electrons on moving pathways.引导沿移动轨迹运动的电子。
Acc Chem Res. 2009 Oct 20;42(10):1669-78. doi: 10.1021/ar900123t.
7
Electron transfer from cytochrome b5 to cytochrome c.电子从细胞色素b5转移至细胞色素c。
J Bioenerg Biomembr. 1995 Jun;27(3):331-40. doi: 10.1007/BF02110102.
8
Biological charge transfer via flickering resonance.生物电荷通过闪烁共振转移。
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10049-54. doi: 10.1073/pnas.1316519111. Epub 2014 Jun 25.
9
Electron Bifurcation: Thermodynamics and Kinetics of Two-Electron Brokering in Biological Redox Chemistry.电子分支：生物氧化还原化学中两电子代理的热力学和动力学。
Acc Chem Res. 2017 Sep 19;50(9):2410-2417. doi: 10.1021/acs.accounts.7b00327. Epub 2017 Sep 6.
10
Electron shuttle between membrane-bound cytochrome P450 3A4 and b5 rules uncoupling mechanisms.膜结合细胞色素P450 3A4与b5之间的电子穿梭决定解偶联机制。
Biochemistry. 1998 Aug 18;37(33):11412-24. doi: 10.1021/bi980908q.
引用本文的文献
1
Conductance Channels in a Single-Entity Enzyme.单体酶中的电导通道。
J Phys Chem Lett. 2024 Oct 31;15(43):10795-10801. doi: 10.1021/acs.jpclett.4c01796. Epub 2024 Oct 21.
2
The critical role of a conserved lysine residue in periplasmic nitrate reductase catalyzed reactions.一个保守赖氨酸残基在周质硝酸还原酶催化反应中的关键作用。
J Biol Inorg Chem. 2024 Jun;29(4):395-405. doi: 10.1007/s00775-024-02057-x. Epub 2024 May 23.
3
Insights into PSII's SY State: An Electronic and Magnetic Analysis.对光系统II的SY态的见解：电子与磁分析
J Phys Chem Lett. 2024 Jan 18;15(2):499-506. doi: 10.1021/acs.jpclett.3c03026. Epub 2024 Jan 8.
4
Liquid-Liquid Phase Separation of the Intrinsically Disordered Domain of the Fused in Sarcoma Protein Results in Substantial Slowing of Hydration Dynamics.融合基因肉瘤蛋白无序结构域的液-液相分离导致水合动力学显著减慢。
J Phys Chem Lett. 2023 Dec 14;14(49):11224-11234. doi: 10.1021/acs.jpclett.3c02790. Epub 2023 Dec 6.
5
A 2.2 Å cryoEM structure of a quinol-dependent NO Reductase shows close similarity to respiratory oxidases.一种依赖于喹啉的 NO 还原酶的 2.2 Å 冷冻电镜结构显示与呼吸氧化酶具有高度相似性。
Nat Commun. 2023 Jun 9;14(1):3416. doi: 10.1038/s41467-023-39140-x.
6
Ordered Motions in the Nitric-Oxide Dioxygenase Mechanism of Flavohemoglobin and Assorted Globins with Tightly Coupled Reductases.黄素血红蛋白及与紧密偶联还原酶结合的各类球蛋白的一氧化氮双加氧酶机制中的有序运动
Adv Exp Med Biol. 2023;1414:45-96. doi: 10.1007/5584_2022_751.
7
Ultrafast Dynamics and Catalytic Mechanism of Fatty Acid Photodecarboxylase.脂肪酸脱羧酶的超快动力学和催化机制。
Angew Chem Int Ed Engl. 2022 Dec 12;61(50):e202209180. doi: 10.1002/anie.202209180. Epub 2022 Nov 10.
8
Interdomain Interactions Modulate the Active Site Dynamics of Human Inducible Nitric Oxide Synthase.域间相互作用调节人诱导型一氧化氮合酶的活性位点动力学。
J Phys Chem B. 2022 Sep 15;126(36):6811-6819. doi: 10.1021/acs.jpcb.2c04091. Epub 2022 Sep 3.
9
Role of the Triplet State and Protein Dynamics in the Formation and Stability of the Tryptophan Radical in an Apoazurin Mutant.色氨酸自由基在脱辅基铜蓝蛋白突变体中的形成和稳定性：三重态态和蛋白质动力学的作用。
J Phys Chem B. 2022 Sep 15;126(36):6751-6761. doi: 10.1021/acs.jpcb.2c02441. Epub 2022 Aug 17.
10
Expanding the reactivity of inorganic clusters towards proteins: the interplay between the redox and hydrolytic activity of Ce(iv)-substituted polyoxometalates as artificial proteases.拓展无机簇对蛋白质的反应活性：铈（IV）取代的多金属氧酸盐作为人工蛋白酶时氧化还原活性与水解活性之间的相互作用
Chem Sci. 2021 Jul 16;12(31):10655-10663. doi: 10.1039/d1sc02760c. eCollection 2021 Aug 11.
本文引用的文献
1
Wet electrons at the H2O/TiO2(110) surface.H2O/TiO2(110)表面的湿电子。
Science. 2005 May 20;308(5725):1154-8. doi: 10.1126/science.1109366.
2
Interprotein electron transfer from cytochrome c2 to photosynthetic reaction center: tunneling across an aqueous interface.从细胞色素c2到光合反应中心的蛋白间电子转移：跨越水相界面的隧穿效应
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3558-63. doi: 10.1073/pnas.0409600102. Epub 2005 Feb 28.
3
Protein dynamics and electron transfer: electronic decoherence and non-Condon effects.蛋白质动力学与电子转移：电子退相干和非康登效应。
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3552-7. doi: 10.1073/pnas.0409047102. Epub 2005 Feb 28.
4
Long-range electron transfer.长程电子转移
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3534-9. doi: 10.1073/pnas.0408029102. Epub 2005 Feb 28.
5
Electron tunneling through organic molecules in frozen glasses.电子隧穿冷冻玻璃态中的有机分子。
Science. 2005 Jan 7;307(5706):99-102. doi: 10.1126/science.1103818.
6
Observation of large water-cluster anions with surface-bound excess electrons.表面结合过量电子的大水簇阴离子的观测。
Science. 2005 Jan 7;307(5706):93-6. doi: 10.1126/science.1106719. Epub 2004 Dec 16.
7
Investigation of the pathway for inter-copper electron transfer in peptidylglycine alpha-amidating monooxygenase.肽基甘氨酸α-酰胺化单加氧酶中铜间电子转移途径的研究。
J Am Chem Soc. 2004 Oct 20;126(41):13168-9. doi: 10.1021/ja046888z.
8
Refinement and structural analysis of bovine cytochrome b5 at 1.5 A resolution.牛细胞色素b5在1.5埃分辨率下的优化与结构分析。
Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):65-76. doi: 10.1107/S0907444995007827.
9
Electron tunneling through proteins.电子通过蛋白质的隧穿
Q Rev Biophys. 2003 Aug;36(3):341-72. doi: 10.1017/s0033583503003913.
10
Dynamic docking and electron-transfer between cytochrome b5 and a suite of myoglobin surface-charge mutants. Introduction of a functional-docking algorithm for protein-protein complexes.细胞色素b5与一组肌红蛋白表面电荷突变体之间的动态对接和电子转移。蛋白质-蛋白质复合物功能对接算法的引入。
J Am Chem Soc. 2004 Mar 10;126(9):2785-98. doi: 10.1021/ja038163l.
Zotero 插件