Friedmann A, Coward J E, Rosenkranz H S, Morgan C
J Gen Virol. 1975 Feb;26(2):171-81. doi: 10.1099/0022-1317-26-2-171.
The release of hydroxyurea-treated, herpes simplex virus-infected cells from the drug-induced block resulted in the prompt assembly of infectious virus. Electron microscope observations at sequential intervals following removal of the drug revealed considerable synchrony of replication. This synchrony permitted stages in the complex process of core assembly to be examined in detail. The data suggest that after partial or complete assembly the nucleoprotein enters the differentiated capsid to become enfolded.
用羟基脲处理过的单纯疱疹病毒感染细胞从药物诱导的阻滞中释放后，迅速组装成有感染性的病毒。去除药物后在连续间隔时间进行的电子显微镜观察显示复制具有相当的同步性。这种同步性使得核心组装这一复杂过程的各个阶段得以详细研究。数据表明，在部分或完全组装后，核蛋白进入分化的衣壳并被包裹起来。
