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修饰对某些嗜B性鼠白血病病毒易感性的新基因座。

New gene locus modifying susceptibility to certain B-tropic murine leukemia viruses.

作者信息

Declève A, Niwa O, Kojola J, Kaplan H S

出版信息

Proc Natl Acad Sci U S A. 1976 Feb;73(2):585-90. doi: 10.1073/pnas.73.2.585.

DOI:10.1073/pnas.73.2.585
PMID:174115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC335955/
Abstract

A new gene, SRV, the dominant allele of which occurs in mice of strain C57BL, independently modifies the slope ("hitness") and level of sensitivity of the titration curves obtained when one subclass of B-tropic murine leukemia viruses is propagated on mouse embryo cells of nonpermissive Fv-1 genotypes. Replication of another subclass of B-tropic viruses is not modified with respect to hitness, and that of N-tropic viruses is not affected.

摘要

一个新基因SRV，其显性等位基因出现在C57BL品系小鼠中，当一类嗜B性鼠白血病病毒在非允许性Fv-1基因型的小鼠胚胎细胞上增殖时，该基因独立地改变所获得的滴定曲线的斜率（“适应性”）和敏感性水平。另一类嗜B性病毒的复制在适应性方面未被改变，而嗜N性病毒的复制则不受影响。

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本文引用的文献

1
Derivation of a murine lymphoid leukemia virus.一种鼠类淋巴白血病病毒的衍生
J Natl Cancer Inst. 1962 Jun;28:1291-303.
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Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice.小鼠辐射诱导淋巴肿瘤滤液的致白血病活性。
Science. 1959 Aug 14;130(3372):387-8. doi: 10.1126/science.130.3372.387.
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Inheritance of susceptibility to Friend mouse leukemia virus. V. Introduction of a gene responsible for susceptibility in the genetic complement of resistant mice.对弗瑞德小鼠白血病病毒易感性的遗传。V. 将负责易感性的基因引入抗性小鼠的遗传互补中。
J Virol. 1969 Jun;3(6):543-8. doi: 10.1128/JVI.3.6.543-548.1969.
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Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice.Fv-2：小鼠中控制对Friend白血病病毒的脾集落反应的第二个基因的鉴定与定位
J Natl Cancer Inst. 1970 Jul;45(1):163-9.
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On the natural history of the murine leukemias: presidential address.论鼠白血病的自然史：主席致辞
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Host restriction of friend leukemia virus; fate of input virion RNA.宿主对Friend白血病病毒的限制；输入病毒粒子RNA的命运
Cell. 1974 Aug;2(4):271-7. doi: 10.1016/0092-8674(74)90021-x.
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Rapid in vivo assay for murine lymphatic leukaemia viruses.小鼠淋巴白血病病毒的快速体内检测法
Nature. 1974 Nov 1;252(5478):79-81. doi: 10.1038/252079a0.
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An improved murine leukemia virus immunofluorescence assay.一种改进的鼠白血病病毒免疫荧光测定法。
Virology. 1974 Feb;57(2):491-502. doi: 10.1016/0042-6822(74)90188-3.
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Growth of pseudotypes of vesicular stomatitis virus with N-tropic murine leukemia virus coats in cells resistant to N-tropic viruses.水泡性口炎病毒假型在对N-嗜性病毒具有抗性的细胞中与N-嗜性鼠白血病病毒包膜的生长情况。
J Virol. 1973 Sep;12(3):659-62. doi: 10.1128/JVI.12.3.659-662.1973.
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Host restriction of Friend leukemia virus. Role of the viral outer coat.弗瑞德白血病病毒的宿主限制。病毒外膜的作用。
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2549-53. doi: 10.1073/pnas.70.9.2549.