Smith J S, Orciari L A, Yager P A, Seidel H D, Warner C K
Rabies Laboratory, Centers for Disease Control, Atlanta, Georgia 30333.
J Infect Dis. 1992 Aug;166(2):296-307. doi: 10.1093/infdis/166.2.296.
Nucleotide sequence analysis of a 200-bp region of the nucleoprotein (N) gene of rabies virus differentiated unique genetic groups of rabies virus from samples collected in areas where dog rabies is enzootic in Asia, Africa, Europe, and the Americas. Patterns of nucleotide sequence identified for an outbreak area were conserved in samples collected over three decades. Epidemiologic relationships among isolates were determined by patterns of conserved nucleotide sequence, and the degree of sequence divergence between samples from separate outbreak areas were measured. This approach suggested that a historical reconstruction of events leading to the introduction of rabies into an area would be possible. In this broader view of rabies epidemiology, the cultural legacy of European exploration and colonization may have also included zoonotic disease.
对狂犬病病毒核蛋白（N）基因200碱基对区域的核苷酸序列分析，区分了从亚洲、非洲、欧洲和美洲犬狂犬病呈地方流行的地区采集的样本中狂犬病病毒独特的遗传群体。在一个暴发地区确定的核苷酸序列模式在三十多年间采集的样本中是保守的。通过保守核苷酸序列模式确定分离株之间的流行病学关系，并测量来自不同暴发地区样本之间的序列差异程度。这种方法表明，有可能对导致狂犬病传入一个地区的事件进行历史重建。从狂犬病流行病学的更广泛视角来看，欧洲探索和殖民的文化遗产可能也包括人畜共患病。
