Billson F Mark, Miller-Michau Tammy, Mould John R B, Davidson Michael G
Division of Small Animal Clinical Studies, Department of Veterinary Clinical Studies, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Bearsden, Glasgow, G61 1QH, UK.
Vet Ophthalmol. 2006 Jan-Feb;9(1):45-51. doi: 10.1111/j.1463-5224.2005.00436.x.
To review the clinical presentation and histopathologic findings on a series of cats with orbital fibrotic disease and compare the data to that of humans with sclerosing orbital pseudotumor.
A retrospective study was undertaken, which identified tissue samples from seven cats between 1997 and 2002 with a history of orbital mass effect and pathology characterized by fibrous tissue proliferation.
Information was obtained from medical records for affected cats, including age, sex, clinical signs, management, and outcome, with histopathology re-examined.
Six of seven cats presented with unilateral orbital involvement that progressed to bilateral orbital disease despite treatment. Onset was insidious, evolving over weeks to months and was associated with fixation of orbital structures. Owners of six of the cats opted for euthanasia because of disease progression and pain. Histopathology of affected orbital tissue included extensive fibrosis with encapsulation of normal tissues without characteristics of neoplasia.
Clinical findings and histopathology of globes and orbital tissues in cats bore many similarities to idiopathic sclerosing orbital pseudotumor in humans. In cats, the prognosis for the globe appears to be poor but an elucidation of the pathogenesis and earlier diagnosis coupled with more aggressive treatment modalities as indicated in humans may be beneficial.
回顾一系列患有眼眶纤维化疾病的猫的临床表现和组织病理学发现，并将这些数据与患有硬化性眼眶假瘤的人类的数据进行比较。
进行了一项回顾性研究，确定了1997年至2002年间7只猫的组织样本，这些猫有眼眶肿块效应病史，病理学特征为纤维组织增生。
从受影响猫的病历中获取信息，包括年龄、性别、临床症状、治疗和结局，并重新检查组织病理学。
7只猫中有6只出现单侧眼眶受累，尽管接受了治疗，但仍进展为双侧眼眶疾病。发病隐匿，在数周至数月内逐渐发展，并与眼眶结构固定有关。6只猫的主人因疾病进展和疼痛选择了安乐死。受影响眼眶组织的组织病理学包括广泛纤维化，正常组织被包裹，无肿瘤特征。
猫眼球和眼眶组织的临床发现和组织病理学与人类特发性硬化性眼眶假瘤有许多相似之处。在猫中，眼球的预后似乎很差，但阐明发病机制、早期诊断以及如人类所示采用更积极的治疗方式可能会有益。
