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本文引用的文献

1
Triterpenoid liquorice compound in gastric and duodenal ulcer.三萜类甘草化合物与胃溃疡和十二指肠溃疡
Lancet. 1962 Dec 1;2(7266):1166-7. doi: 10.1016/s0140-6736(62)90926-1.
2
Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.甘草甜素，甘草根的一种活性成分，与严重急性呼吸综合征相关冠状病毒的复制
Lancet. 2003 Jun 14;361(9374):2045-6. doi: 10.1016/s0140-6736(03)13615-x.
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Efficacy of a glycyrrhizin suppository for the treatment of chronic hepatitis C: a pilot study.
Hepatol Res. 2003 May;26(1):10-14. doi: 10.1016/s1386-6346(02)00332-7.
4
Medicinal herbs for hepatitis C virus infection: a Cochrane hepatobiliary systematic review of randomized trials.用于丙型肝炎病毒感染的草药：Cochrane肝胆系统随机试验综述
Am J Gastroenterol. 2003 Mar;98(3):538-44. doi: 10.1111/j.1572-0241.2003.07298.x.
5
Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine.甘草酸的化学修饰作为一种获取新型药用生物活性化合物的途径。
Curr Med Chem. 2003 Jan;10(2):155-71. doi: 10.2174/0929867033368538.
6
Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.菊科植物的成分III. 食用菊花中三萜二醇和三萜三醇对人类癌细胞系的抗肿瘤促进作用和细胞毒性活性。
Cancer Lett. 2002 Mar 8;177(1):7-12. doi: 10.1016/s0304-3835(01)00769-8.
7
Efficient method for determining the glycyrrhizin content of fresh and dried roots, and root extracts, of Glycyrrhiza species.测定甘草属植物新鲜和干燥根及根提取物中甘草酸含量的高效方法。
Phytochem Anal. 2001 Sep-Oct;12(5):332-5. doi: 10.1002/pca.597.
8
Simultaneous determination of glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid mono-glucuronide in Shakuyaku-kanzo-to incubated with rat feces by semi-micro high-performance liquid chromatography.
Biol Pharm Bull. 2001 Oct;24(10):1161-4. doi: 10.1248/bpb.24.1161.
9
Review article: glycyrrhizin as a potential treatment for chronic hepatitis C.综述文章：甘草酸作为慢性丙型肝炎的潜在治疗方法
Aliment Pharmacol Ther. 1998 Mar;12(3):199-205. doi: 10.1046/j.1365-2036.1998.00309.x.
10
Identification of glycyrrhizin as a thrombin inhibitor.甘草甜素作为凝血酶抑制剂的鉴定。
Biochem Biophys Res Commun. 1997 Jun 9;235(1):259-63. doi: 10.1006/bbrc.1997.6735.

采用等度洗脱的高效液相色谱法同时分析甘草根及糖果制品中的甘草酸和甘草次酸。

Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products.

作者信息

Sabbioni Cesare, Ferranti Anna, Bugamelli Francesca, Forti Giorgio Cantelli, Raggi Maria Augusta

机构信息

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.

出版信息

Phytochem Anal. 2006 Jan-Feb;17(1):25-31. doi: 10.1002/pca.877.

DOI:10.1002/pca.877
PMID:16454473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7167644/
Abstract

Glycyrrhizin (1), the main active principle of Glycyrrhiza glabra (liquorice) roots, is extensively used in herbal medicines, in pharmaceutical preparations and confectionery products. A feasible and reliable method which allows the simultaneous analysis of 1 and its aglycone, 18beta-glycyrrhetic acid (2), by means of an isocratic HPLC procedure is described. The system uses a C8 column as the stationary phase, and a mixture of acetonitrile, methanol, water and glacial acetic acid as the mobile phase. Good linearity was found in the concentration ranges 1-50 and 0.05-2.50 microg/mL for 1 and 2, respectively. A simple and rapid sample pre-treatment, based on the extraction of the two analytes with a mixture of water and ethanol, was developed for the examination of liquorice confectionery products and root samples. The HPLC method was shown to be appropriate, in terms of precision and feasibility, for the quality control of the analytes in these matrices.

摘要

甘草甜素（1）是光果甘草根的主要活性成分，广泛应用于草药、药物制剂和糖果产品中。本文描述了一种可行且可靠的方法，该方法可通过等度高效液相色谱法同时分析1及其苷元18β-甘草次酸（2）。该系统使用C8柱作为固定相，乙腈、甲醇、水和冰醋酸的混合物作为流动相。1和2的浓度范围分别为1 - 50和0.05 - 2.50μg/mL时，线性关系良好。基于用水和乙醇混合物萃取两种分析物，开发了一种简单快速的样品预处理方法，用于检测甘草糖果产品和根样品。就精密度和可行性而言，高效液相色谱法适用于这些基质中分析物的质量控制。