Kupradinun S, Peanpijit P, Bhodhikosoom C, Yoshioka Y, Endo A, Nerome K
Department of Medical Sciences, 88/7 Soi Bamrasnaradura Hospital, Nonthaburi, Thailand.
Arch Virol. 1991;118(3-4):289-97. doi: 10.1007/BF01314040.
Two influenza A viruses were isolated from pigs in Thailand in January 1988 during the early febrile stage of an influenza-like illness. The isolates contained hemagglutinin and neuraminidase antigens related to those of swine H1N1 influenza virus. This result based on the virus isolation is compatible with the epizootiological evidence that, unlike the human influenza with peak activity in summer (May-July), swine influenza virus is prevalent in the winter season (November-January) in Thailand. The proportion of sera with hemagglutination-inhibiting antibody was higher to A/NJ/8/76 than to A/sw/Iowa/15/30. Likewise, hemagglutination-inhibition tests with monoclonal antibodies indicated that hemagglutinin antigen of the isolates was very similar to that of A/NJ/8/76 virus. In agreement with the serological survey and antigenic characteristic, genetic relatedness between the isolates from Thailand and A/NJ/8/76 virus was also demonstrated by the oligonucleotide mapping of RNA, suggesting that they may be of the same origin.
1988年1月，在泰国，从患有流感样疾病发热初期的猪身上分离出两株甲型流感病毒。分离出的病毒含有与猪H1N1流感病毒相关的血凝素和神经氨酸酶抗原。基于病毒分离的这一结果与流行病学证据相符，即与夏季（5月至7月）出现活动高峰的人流感不同，泰国猪流感病毒在冬季（11月至1月）流行。具有血凝抑制抗体的血清比例对A/NJ/8/76比对A/sw/Iowa/15/30更高。同样，用单克隆抗体进行的血凝抑制试验表明，分离出的病毒的血凝素抗原与A/NJ/8/76病毒的血凝素抗原非常相似。与血清学调查和抗原特性一致，通过RNA的寡核苷酸图谱也证明了泰国分离出的病毒与A/NJ/8/76病毒之间的遗传相关性，这表明它们可能起源相同。
