Piatti P G, Berinstein A, Lopez O J, Borca M V, Fernandez F, Schudel A A, Sadir A M
Institute of Virology, CICV, INTA-Castelar, Argentina.
J Gen Virol. 1991 Jul;72 ( Pt 7):1691-4. doi: 10.1099/0022-1317-72-7-1691.
The immune response to foot-and-mouth disease virus (FMDV) elicited by infection or immunization with inactivated virus in adult mice was examined. A model of adoptive transfer of immunocompetent cells was used for this purpose. The results presented here indicate that both short- and long-term secondary immune responses elicited by high doses of inactivated virus are indistinguishable, at the humoral or cellular level, from that observed after infection. The responses to inactivated or infectious virus were both efficiently mediated by B cells. However, immunization with low doses of inactivated virus induced a response which, although effective in aborting infection, was fully dependent on FMDV-specific T cell cooperation. These findings suggest that the different immune responses observed after infection and immunization are mainly the result of the different viral mass presented to the immune system in each case.
研究了成年小鼠感染口蹄疫病毒（FMDV）或用灭活病毒免疫后引发的免疫反应。为此采用了免疫活性细胞过继转移模型。此处呈现的结果表明，高剂量灭活病毒引发的短期和长期二次免疫反应，在体液或细胞水平上与感染后观察到的反应并无差异。对灭活或感染性病毒的反应均由B细胞有效介导。然而，低剂量灭活病毒免疫诱导的反应虽然在阻止感染方面有效，但完全依赖于FMDV特异性T细胞的协同作用。这些发现表明，感染和免疫后观察到的不同免疫反应主要是由于每种情况下呈现给免疫系统的病毒量不同所致。
