Anderson J W, Gilinsky N H, Deakins D A, Smith S F, O'Neal D S, Dillon D W, Oeltgen P R
Endocrine-Metabolic Section, VA Medical Center, Lexington 40511.
Am J Clin Nutr. 1991 Oct;54(4):678-83. doi: 10.1093/ajcn/54.4.678.
The hypocholesterolemic effects of oat bran (OB) have been recently challenged. To carefully document the hypocholesterolemic effects of OB, 20 hypercholesterolemic men admitted to a metabolic ward were randomly allocated to either OB or wheat bran (WB) for 21 d after a 7-d control-diet period. Control and treatment diets were designed to be identical in energy content and nutrients, differing only in the amount of soluble fiber. After 21 d, OB significantly decreased total cholesterol by 12.8% (P less than 0.001), low-density-lipoprotein cholesterol by 12.1% (P less than 0.004), and apolipoprotein B-100 by 13.7% (P less than 0.001) whereas WB had no significant effect. High-density-lipoprotein cholesterol and apolipoprotein A-I did not change significantly in either group. Serum triglycerides decreased by 10% in both groups but the decrease was only significant (P less than 0.04) in WB subjects. OB but not WB significantly reduced total cholesterol and other atherogenic lipoprotein fractions independent of other dietary changes.
燕麦麸（OB）的降胆固醇作用最近受到了质疑。为了详细记录OB的降胆固醇作用，20名入住代谢病房的高胆固醇血症男性在经过7天的对照饮食期后，被随机分配到OB组或麦麸（WB）组，为期21天。对照饮食和治疗饮食在能量含量和营养成分上设计相同，仅在可溶性纤维含量上有所不同。21天后，OB使总胆固醇显著降低了12.8%（P<0.001），低密度脂蛋白胆固醇降低了12.1%（P<0.004），载脂蛋白B-100降低了13.7%（P<0.001），而WB没有显著影响。两组的高密度脂蛋白胆固醇和载脂蛋白A-I均无显著变化。两组的血清甘油三酯均下降了10%，但仅在WB组中下降显著（P<0.04）。OB而非WB能显著降低总胆固醇和其他致动脉粥样硬化脂蛋白组分，且不受其他饮食变化的影响。
