Romero A L, Romero J E, Galaviz S, Fernandez M L
Centro de Investigacion y Postgrado, Universidad de Sonora, Hermosillo, Mexico.
J Am Coll Nutr. 1998 Dec;17(6):601-8. doi: 10.1080/07315724.1998.10718809.
Psyllium and oat bran have been shown to lower plasma LDL cholesterol levels in different populations. Hypercholesterolemia is prevalent in the Northern part of Mexico and might be associated to dietary habits and sedentary lifestyle.
Sedentary normal (cholesterol<200 mg/dL) (n=36) and hypercholesterolemic (cholesterol>220 mg/dL) (n=30) men from the Northern part of Mexico aged 20 to 45 years of age participated in an 8-week study to determine the effects of dietary soluble fiber, either psyllium or oat bran, in lowering plasma LDL cholesterol in this population. Fiber was administered by feeding the subjects an amount of cookies (100 g) equivalent to 1.3 or 2.6 g/day of soluble fiber from psyllium or oat bran, respectively. Subjects were randomly allocated to three groups: a control group consuming cookies with wheat bran, a known source of fiber with no cholesterol lowering effects, psyllium, or oat bran.
Food frequency questionnaires indicated that subjects from the three groups had similar intakes of foods classified as hypercholesterolemic (p>0.05). Plasma LDL cholesterol concentrations were reduced by an average of 22.6 and 26% in the psyllium and oat bran groups (p<0.001) while a non-significant reduction of 8.4% was observed in the hypercholesterolemic individuals from the control group. No effects on plasma HDL or triglycerides levels were observed among the three dietary treatments except for hypercholesterolemic individuals supplemented with oat bran where a 28% reduction in plasma triglycerides was observed after 8 weeks (p<0.01).
These results indicate that psyllium and oat bran are efficacious in lowering plasma LDL cholesterol in both normal and hypercholesterolemic individuals from this population.
已证实洋车前子和燕麦麸可降低不同人群的血浆低密度脂蛋白胆固醇水平。高胆固醇血症在墨西哥北部很普遍，可能与饮食习惯和久坐不动的生活方式有关。
来自墨西哥北部年龄在20至45岁之间的久坐不动的正常（胆固醇<200 mg/dL）男性（n = 36）和高胆固醇血症男性（胆固醇>220 mg/dL）（n = 30）参与了一项为期8周的研究，以确定食用洋车前子或燕麦麸等膳食纤维对该人群降低血浆低密度脂蛋白胆固醇的影响。通过给受试者喂食一定量的饼干（100 g）来给予纤维，这些饼干分别相当于每天从洋车前子或燕麦麸中摄取1.3或2.6 g的可溶性纤维。受试者被随机分为三组：一个对照组，食用含有麦麸的饼干，麦麸是一种已知的纤维来源，但没有降低胆固醇的作用；洋车前子组；燕麦麸组。
食物频率问卷表明，三组受试者对高胆固醇食物的摄入量相似（p>0.05）。洋车前子组和燕麦麸组的血浆低密度脂蛋白胆固醇浓度平均降低了22.6%和26%（p<0.001），而对照组的高胆固醇血症个体仅出现了8.4%的非显著性降低。除了高胆固醇血症个体补充燕麦麸后，8周后血浆甘油三酯降低了28%（p<0.01）外，三种饮食治疗对血浆高密度脂蛋白或甘油三酯水平均无影响。
这些结果表明，洋车前子和燕麦麸对该人群的正常个体和高胆固醇血症个体均有降低血浆低密度脂蛋白胆固醇的作用。
