Division of Immunology, Sloan-Kettering Institute and Infectious Disease Service, Department of Medicine, Memorial Hospital, New York, New York 10021.
Infect Immun. 1971 Jan;3(1):159-63. doi: 10.1128/iai.3.1.159-163.1971.
Cytomegaloviremia was documented in seven patients. Three patients were renal transplant recipients and two were liver transplant recipients. One was a postcardiac surgery patient, and one had acute myelogenous leukemia. The transplant patients had received only banked blood or fresh frozen plasma and developed evidence of infection about 1 month after surgery. Illness varied from no apparent signs to fever alone, fever and a morbilliform rash, hepatitis and an infectious mononucleosis syndrome. The virus was isolated from the blood erythrocyte layer, the leukocyte layer, and the plasma and serum, in that order of frequency. In vitro studies demonstrated persistence of inoculated cytomegalovirus in the presence of erythrocytes (and tissue culture media) for up to 21 days. In whole blood under banking conditions, inoculated virus was recovered after 28 days and, in fresh frozen plasma, after 97 days.
七名患者的巨细胞病毒血症得到了记录。其中三名是肾移植受者，两名是肝移植受者。一名是心脏手术后患者，一名患有急性髓细胞性白血病。移植患者仅接受了库存血液或新鲜冷冻血浆，并在手术后约 1 个月出现感染迹象。疾病从无明显症状到仅发热、发热和麻疹样皮疹、肝炎和传染性单核细胞增多症综合征不等。病毒依次从红细胞层、白细胞层和血浆及血清中分离出来。体外研究表明，在存在红细胞（和组织培养基）的情况下，接种的巨细胞病毒可持续存在长达 21 天。在储存条件下的全血中，接种病毒可在 28 天后恢复，而在新鲜冷冻血浆中，可在 97 天后恢复。
