Birosová Lucia, Mikulásová Mária, Vaverková Stefánia
Department of Biochemistry and Microbiology, Faculty of Food and Chemical Technology, Slovak University of Technology, Bratislava, Slovakia.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):489-91. doi: 10.5507/bp.2005.087.
In the present study, the Salmonella typhimurium tester strain TA 100 was used in the plate-incorporation test to examine the antimutagenic potential of caffeic, ferulic and cichoric acids extracted from plant species of genera Echinacea (L) Moench, as well as of another phenolic acids, on 3-(5-nitro-2-furyl)acrylic acid (5NFAA) and sodium azide mutagenicity. All tested compounds possess antimutagenic activity. In the case of 5NFAA, the antimutagenic potency of tested compounds was in the order of gallic acid > ferulic acid > caffeic acid > syringic acid > vanillic acid. The mutagenic effect of sodium azide was inhibited by tested phenolic acids by about 20-35 %. The most effective compound, gallic acid inhibits this effect by 82 % in the concentration of 500 mug/plate. The only exception from favourable properties of tested phenolic acids is cichoric acid, which in the contrary significantly increased the mutagenic effect of 5NFAA.
在本研究中，鼠伤寒沙门氏菌测试菌株TA 100用于平板掺入试验，以检测从紫锥菊属（L）门奇植物物种中提取的咖啡酸、阿魏酸和菊苣酸以及其他酚酸对3 -（5 - 硝基 - 2 - 呋喃基）丙烯酸（5NFAA）和叠氮化钠致突变性的抗诱变潜力。所有测试化合物均具有抗诱变活性。对于5NFAA，测试化合物的抗诱变效力顺序为没食子酸＞阿魏酸＞咖啡酸＞丁香酸＞香草酸。测试酚酸对叠氮化钠的诱变作用抑制约20 - 35%。最有效的化合物没食子酸在浓度为500微克/平板时可抑制该作用82%。测试酚酸良好特性的唯一例外是菊苣酸，相反，它显著增加了5NFAA的诱变作用。
