Yang M, Christoforidis G, Abduljali A, Beversdorf D
Department of Radiology, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.
AJNR Am J Neuroradiol. 2006 Apr;27(4):922-8.
This study investigates physiologic vital signs in subjects, with and without cerebral pathologies, undergoing ultra-high-field (UHF) 8T MR imaging.
Eighteen normal subjects and 74 subjects with cerebral pathology consented for 8T UHF MR imaging. T2*-weighted gradient-echo and T2-weighted rapid acquisition relaxation excitement sequences were used. Physiologic vital signs measured included systolic blood pressure, diastolic blood pressure, mean arterial pressure, electrocardiogram, heart rate (HR), respiratory rate (RR), and pulse oxygen saturation rate. They were collected before, during, and after imaging. Mean vital sign values at different stages were calculated and compared. Subjects were interviewed after imaging.
No adverse vital sign change was detected. Statistically significant changes after imaging included a HR decrease from 65.2 beats per minute (bpm) to 60.3 bpm (P = .001, paired Student t test) in the normal group and a RR increase from 14.5 respirations per minute (rpm) to 15.1 rpm (P = .001, paired Student t test) in the patient group. Transient vertigo sensation was reported by 27% of normal subjects and 11% of subjects with cerebral pathologies. One normal subject and one subject with cerebral pathology reported an episode of nausea and vomiting.
The current neurologic human MR imaging procedure at 8T UHF has no serious adverse effects on major physiologic vital signs in either normal subjects or patients. Transient vertigo, nausea, and vomiting were identified as potential risks.
本研究调查了患有和未患有脑部病变的受试者在接受超高场（UHF）8T磁共振成像时的生理生命体征。
18名正常受试者和74名患有脑部病变的受试者同意接受8T UHF磁共振成像。使用了T2 *加权梯度回波和T2加权快速采集弛豫激发序列。测量的生理生命体征包括收缩压、舒张压、平均动脉压、心电图、心率（HR）、呼吸频率（RR）和脉搏血氧饱和度。在成像前、成像期间和成像后收集这些数据。计算并比较不同阶段的平均生命体征值。成像后对受试者进行了访谈。
未检测到生命体征的不良变化。成像后有统计学意义的变化包括正常组的心率从每分钟65.2次搏动（bpm）降至60.3 bpm（P = .001，配对学生t检验），患者组的呼吸频率从每分钟14.5次呼吸（rpm）增至15.1 rpm（P = .001，配对学生t检验）。27%的正常受试者和11%的脑部病变受试者报告有短暂眩晕感。一名正常受试者和一名脑部病变受试者报告有恶心和呕吐发作。
当前8T UHF的神经学人体磁共振成像程序对正常受试者或患者的主要生理生命体征均无严重不良影响。短暂眩晕、恶心和呕吐被确定为潜在风险。
