在经X射线照射的低过氧化氢酶血症小鼠（C3H/Cbs）中诱导印戒细胞癌。
Induction of signet ring cell carcinomas in X-irradiated hypocatalasemic mice (C3H/Cbs).
作者信息
Watanabe H, Ogundigie P O, Takahashi T, Ishimoto T, Ito A
机构信息
Department of Cancer Research, Hiroshima University.
出版信息
Jpn J Cancer Res. 1991 Nov;82(11):1175-7. doi: 10.1111/j.1349-7006.1991.tb01774.x.
The stomach region of hypocatalasemic mice of both sexes was X-irradiated once with a dose of 20 Gy. Thirteen months after the irradiation, 3 out of 13 (20%) males and 2 out of 9 (15%) females were observed to have developed signet ring cell carcinomas in the glandular stomach. This finding was statistically significant (P less than 0.01 in males and P less than 0.05 in females) compared to a total absence of similar tumors in the non-irradiated controls. Local invasion of malignant tumors into muscle and subserosal layers was observed, but no metastatic tumors were found in distant organs.
对两性的低过氧化氢酶血症小鼠的胃部进行一次20 Gy剂量的X射线照射。照射后13个月，观察到13只雄性小鼠中有3只（20%）以及9只雌性小鼠中有2只（15%）在腺胃中发生了印戒细胞癌。与未照射的对照组完全没有类似肿瘤相比，这一发现具有统计学意义（雄性P<0.01，雌性P<0.05）。观察到恶性肿瘤局部侵犯至肌肉层和浆膜下层，但在远处器官未发现转移瘤。
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