18型人乳头瘤病毒DNA在一例咽癌和一例喉癌中的存在情况
Presence of human papillomavirus type 18 DNA in a pharyngeal and a laryngeal carcinoma.
作者信息
Ogura H, Watanabe S, Fukushima K, Masuda Y, Fujiwara T, Yabe Y
机构信息
Department of Molecular Virology, Okayama University Medical School.
出版信息
Jpn J Cancer Res. 1991 Nov;82(11):1184-6. doi: 10.1111/j.1349-7006.1991.tb01776.x.
Abstract
We examined the presence of human papillomavirus (HPV) genome in pharyngeal and laryngeal squamous cell carcinomas by employing the polymerase chain reaction. We detected HPV 16 DNA in one of 11 pharyngeal carcinomas and in 3 of 28 laryngeal carcinomas, and HPV 18 DNA in a pharyngeal and a laryngeal carcinoma. In one of the laryngeal carcinomas, DNA of both HPV types 16 and 18 were detected. To our knowledge, this is the first report of detection of HPV type 18 in head and neck carcinomas.
摘要
我们通过聚合酶链反应检测了咽喉部鳞状细胞癌中人乳头瘤病毒（HPV）基因组的存在情况。我们在11例咽癌中的1例以及28例喉癌中的3例中检测到了HPV 16 DNA，在1例咽癌和1例喉癌中检测到了HPV 18 DNA。在1例喉癌中，同时检测到了HPV 16型和18型的DNA。据我们所知，这是头颈部癌中检测到HPV 18型的首次报告。
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