Mukaino Tatsuya, Koga Takeharu, Oshita Yuichi, Narita Yuko, Obata Susumu, Aizawa Hisamichi
First Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume 830-0011, Japan.
Respir Med. 2006 Nov;100(11):2069-71. doi: 10.1016/j.rmed.2006.03.003. Epub 2006 Apr 12.
A 54-year-old female presented with an exacerbation of right middle lobe bronchiectasis. A bronchoscopic bronchial washing and repeated trials of sputum culture consistently recovered no other infectious agent except Exophiala dermatitidis. Her illness was improved by administrations of intravenous miconazole and nebulized amphotericin B when sputum cultures yielded no fungi, demonstrating a pathogenic role of the fungi. The present case illustrates E. dermatitidis as a pathogenic agent in non-cystic fibrosis bronchiectasis.
一名54岁女性因右中叶支气管扩张症加重前来就诊。支气管镜下支气管灌洗及多次痰培养，除皮炎外瓶霉外，均未发现其他感染病原体。当痰培养未发现真菌时，静脉注射咪康唑和雾化两性霉素B使她的病情得到改善，这表明真菌具有致病作用。本病例表明皮炎外瓶霉是一种非囊性纤维化支气管扩张症的病原体。
