Henley Derek V, Korach Kenneth S
Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.
Endocrinology. 2006 Jun;147(6 Suppl):S25-32. doi: 10.1210/en.2005-1117. Epub 2006 May 11.
The term endocrine-disrupting chemicals is used to define a structurally diverse class of synthetic and natural compounds that possess the ability to alter various components of the endocrine system and potentially induce adverse health effects in exposed individuals and populations. Research on these compounds has revealed that they use a variety of both nuclear receptor-mediated and non-receptor-mediated mechanisms to modulate different components of the endocrine system. This review will describe in vitro and in vivo studies that highlight the spectrum of unique mechanisms of action and biological effects of four endocrine-disrupting chemicals--diethylstilbestrol, genistein, di(n-butyl)phthalate, and methoxyacetic acid--to illustrate the diverse and complex nature of this class of compounds.
内分泌干扰化学物质这一术语用于定义一类结构多样的合成和天然化合物，这些化合物能够改变内分泌系统的各个组成部分，并可能在接触的个体和人群中引发不良健康影响。对这些化合物的研究表明，它们利用多种核受体介导和非受体介导的机制来调节内分泌系统的不同组成部分。本综述将描述体外和体内研究，这些研究突出了四种内分泌干扰化学物质——己烯雌酚、染料木黄酮、邻苯二甲酸二丁酯和甲氧基乙酸——独特的作用机制和生物学效应范围，以阐明这类化合物的多样性和复杂性。
