Thong Y H, Vincent M M, Hensen S A, Fuccillo D A, Rola-Pleszczynski M, Bellanti J A
Infect Immun. 1975 Jul;12(1):76-80. doi: 10.1128/iai.12.1.76-80.1975.
Cell-mediated immunity to herpes simplex virus type 1 (HSV-1) was assessed by a lymphocytotoxicity 51-Cr-release microassay procedure, using the MA-160 human prostatic adenoma cell line chronically infected with HSV-1 and its parent cell line as control. The specific immune release mean plus or minus standard deviation for nine asymptomatic patients with recurrent HSV-1 infections was 13.7 plus or minus 8.1%, compared to 28.9 plus or minus 8.4% in seven normal seropositive controls (P is less than 0.01). In four additional patients studied serially, the cell-mediated immunity was significantly increased during the recrudescence of herpetic infection, with a mean specific immune release value of 51.7 plus or minus 27.8%, compared to 8.7 plus or minus 1.5% during the convalescent period 2 to 10 weeks later (P is less than 0.05). These findings suggest that patients with recurrent HSV-1 infections have vigorous cellular immune responses during the acute phase but a specific impairment of cell-mediated immunity during the quiescent period, which may in part account for their susceptibility to recurrent herpetic infections.
采用淋巴细胞毒性51铬释放微量测定法，以长期感染单纯疱疹病毒1型（HSV-1）的MA-160人前列腺腺癌细胞系及其亲本细胞系作为对照，评估针对HSV-1的细胞介导免疫。9例复发性HSV-1感染无症状患者的特异性免疫释放平均值±标准差为13.7±8.1%，而7例正常血清学阳性对照者为28.9±8.4%（P<0.01）。在另外4例进行连续研究的患者中，疱疹感染复发期间细胞介导免疫显著增强，平均特异性免疫释放值为51.7±27.8%，而在2至10周后的恢复期为8.7±1.5%（P<0.05）。这些发现表明，复发性HSV-1感染患者在急性期有强烈的细胞免疫反应，但在静止期存在细胞介导免疫的特异性损害，这可能部分解释了他们易患复发性疱疹感染的原因。
