Kronen Peter W, Ludders John W, Erb Hollis N, Moon Paula F, Gleed Robin D, Koski Sharon
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Vet Anaesth Analg. 2006 Jul;33(4):258-65. doi: 10.1111/j.1467-2995.2005.00265.x.
To evaluate whether a synthetic analogue of feline facial pheromone (FFP) calms cats before, and reduces struggling during intravenous catheterization.
Block-randomized, 'blinded' clinical trial.
Seventy-seven healthy cats presented for elective surgery.
Cats given glycopyrrolate and oxymorphone were assigned to one of four treatments: acepromazine and exposure to FFP (aceFFP); acepromazine and exposure to a placebo (acePlac); exposure to FFP only (FFP) and exposure to placebo only (Plac). The behaviour of cats was recorded on videotape for evaluation by assessors unaware of treatment group. Cats' veins were then catheterized by veterinary students unaware of the study protocol. Based on each cat's response to catheterization, the student independently decided whether intramuscular ketamine was required.
Cats in the aceFFP group appeared to be calmer than acePlac cats on the basis of head position and their location in the cage (suggesting benefit from FFP among cats receiving acepromazine) but appeared to be less sedated. Cats in the aceFFP group also appeared to be calmer than FFP cats on the basis of head position and location in the cage. Feline facial pheromone cats were also calmer than Plac cats when compared using body and leg position. Exposure to FFP did not significantly reduce struggling at catheterization, nevertheless, the students were able to catheterize the veins in all cats.
There were no detrimental behavioural effects associated with either FFP or acepromazine. The FFP had additional calming effects in cats given acepromazine and, to a lesser degree, helped to calm cats that were not given acepromazine. Feline facial pheromone helps to calm cats in unfamiliar surroundings.
评估猫面部信息素（FFP）的合成类似物在静脉插管前是否能使猫平静下来，并减少插管过程中的挣扎。
区组随机、“盲法”临床试验。
77只接受择期手术的健康猫。
给予格隆溴铵和羟吗啡酮的猫被分配到四种治疗方法之一：乙酰丙嗪并接触FFP（乙酰丙嗪+FFP）；乙酰丙嗪并接触安慰剂（乙酰丙嗪+安慰剂）；仅接触FFP（FFP）；仅接触安慰剂（安慰剂）。将猫的行为录制成视频，由不知道治疗组情况的评估人员进行评估。然后，不了解研究方案的兽医学生为猫进行静脉插管。根据每只猫对插管的反应，学生独立决定是否需要肌肉注射氯胺酮。
基于头部位置和在笼中的位置，乙酰丙嗪+FFP组的猫似乎比乙酰丙嗪+安慰剂组的猫更平静（表明在接受乙酰丙嗪的猫中FFP有益），但镇静程度似乎较低。基于头部位置和在笼中的位置，乙酰丙嗪+FFP组的猫似乎也比FFP组的猫更平静。使用身体和腿部位置进行比较时，接触FFP的猫也比安慰剂组的猫更平静。接触FFP并没有显著减少插管时的挣扎，不过，学生们能够为所有的猫成功进行静脉插管。
FFP和乙酰丙嗪均未产生有害的行为影响。FFP对给予乙酰丙嗪的猫有额外的镇静作用，对未给予乙酰丙嗪的猫也有一定程度的镇静作用。猫面部信息素有助于使处于陌生环境中的猫平静下来。
