Arcury Thomas A, Grzywacz Joseph G, Davis Stephen W, Barr Dana B, Quandt Sara A
Department of Family and Community Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1084, USA.
Am J Ind Med. 2006 Sep;49(9):751-60. doi: 10.1002/ajim.20354.
Organophosphorus (OP) pesticide urinary metabolite levels in a sample of farmworker children in North Carolina are documented and compared to national reference data. The relative importance of para-occupational, residential, and environment risk factors are delineated.
Urine samples were collected from 60 farmworker children 1-6 years of age, and interviews were completed by their mothers. Urine samples were analyzed for the dialkylphosphate (DAP) metabolites of OP pesticides. Summed molar concentrations of the diethyl and dimethyl DAP metabolites provided summary measures.
The farmworker children had relatively high levels of OP pesticide urinary metabolites compared to national reference data; for example, participating children had higher geometric means for diethylphosphate (DEP), diethylthiophosphate (DETP), and the summed diethyl metabolites. However, analyses found no pattern of significant associations between predictors and metabolite levels.
Future research requires greater precision in sampling and measurement to determine the risk factors for pesticide exposure among farmworker children.
记录了北卡罗来纳州农场工人子女样本中有机磷（OP）农药尿液代谢物水平，并与国家参考数据进行比较。明确了职业、居住和环境等相关危险因素的相对重要性。
收集了60名1至6岁农场工人子女的尿液样本，并由他们的母亲完成访谈。对尿液样本进行有机磷农药二烷基磷酸酯（DAP）代谢物分析。二乙基和二甲基DAP代谢物的总摩尔浓度提供了汇总指标。
与国家参考数据相比，农场工人子女的有机磷农药尿液代谢物水平相对较高；例如，参与研究的儿童在磷酸二乙酯（DEP）、硫代磷酸二乙酯（DETP）和二乙基代谢物总和方面的几何平均值更高。然而，分析发现预测因素与代谢物水平之间没有显著关联模式。
未来的研究需要在采样和测量方面提高精度，以确定农场工人子女农药暴露的危险因素。
