杀精剂苯扎氯铵对组织培养液和生殖分泌物中1型人类免疫缺陷病毒的灭活作用。
Inactivation of human immunodeficiency virus type 1 in tissue culture fluid and in genital secretions by the spermicide benzalkonium chloride.
作者信息
Wainberg M A, Spira B, Bleau G, Thomas R
机构信息
Jewish General Hospital, Montreal, Quebec, Canada.
出版信息
J Clin Microbiol. 1990 Jan;28(1):156-8. doi: 10.1128/jcm.28.1.156-158.1990.
Abstract
We have shown that the spermicidal agent benzalkonium chloride can exert a direct inhibitory effect on the viral reverse transcriptase activity of human immunodeficiency virus type 1 (HIV-1) when utilized at concentrations of 0.05% and higher. Exposure of HIV-1 to this disinfectant at concentrations of more than 0.05% was able to completely destroy viral infectivity, as assessed on susceptible target cells. We have further shown that HIV-1, which is present in both seminal and genital secretions, can be inactivated in such fluids by direct exposure to benzalkonium chloride.
摘要
我们已经表明，当使用浓度为0.05%及更高时，杀精剂苯扎氯铵可对1型人类免疫缺陷病毒（HIV-1）的病毒逆转录酶活性产生直接抑制作用。将HIV-1暴露于浓度超过0.05%的这种消毒剂中，能够完全破坏病毒感染性，这是在易感靶细胞上评估得出的。我们还进一步表明，精液和生殖器分泌物中存在的HIV-1，通过直接暴露于苯扎氯铵可在此类液体中失活。
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