杀精剂苯扎氯铵对组织培养液和生殖分泌物中1型人类免疫缺陷病毒的灭活作用。
Inactivation of human immunodeficiency virus type 1 in tissue culture fluid and in genital secretions by the spermicide benzalkonium chloride.
作者信息
Wainberg M A, Spira B, Bleau G, Thomas R
机构信息
Jewish General Hospital, Montreal, Quebec, Canada.
出版信息
J Clin Microbiol. 1990 Jan;28(1):156-8. doi: 10.1128/jcm.28.1.156-158.1990.
Abstract
We have shown that the spermicidal agent benzalkonium chloride can exert a direct inhibitory effect on the viral reverse transcriptase activity of human immunodeficiency virus type 1 (HIV-1) when utilized at concentrations of 0.05% and higher. Exposure of HIV-1 to this disinfectant at concentrations of more than 0.05% was able to completely destroy viral infectivity, as assessed on susceptible target cells. We have further shown that HIV-1, which is present in both seminal and genital secretions, can be inactivated in such fluids by direct exposure to benzalkonium chloride.
摘要
我们已经表明，当使用浓度为0.05%及更高时，杀精剂苯扎氯铵可对1型人类免疫缺陷病毒（HIV-1）的病毒逆转录酶活性产生直接抑制作用。将HIV-1暴露于浓度超过0.05%的这种消毒剂中，能够完全破坏病毒感染性，这是在易感靶细胞上评估得出的。我们还进一步表明，精液和生殖器分泌物中存在的HIV-1，通过直接暴露于苯扎氯铵可在此类液体中失活。
相似文献
1
Inactivation of human immunodeficiency virus type 1 in tissue culture fluid and in genital secretions by the spermicide benzalkonium chloride.杀精剂苯扎氯铵对组织培养液和生殖分泌物中1型人类免疫缺陷病毒的灭活作用。
J Clin Microbiol. 1990 Jan;28(1):156-8. doi: 10.1128/jcm.28.1.156-158.1990.
2
The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro.杀精剂对单纯疱疹病毒2型和人类免疫缺陷病毒1型体外复制的抑制作用。
J Antimicrob Chemother. 1993 Jul;32(1):71-82. doi: 10.1093/jac/32.1.71.
3
The activity of candidate virucidal agents, low pH and genital secretions against HIV-1 in vitro.
Int J STD AIDS. 1995 Jul-Aug;6(4):267-72. doi: 10.1177/095646249500600409.
4
Spermicidal and antiviral properties of cholic acid: contraceptive efficacy of a new vaginal sponge (Protectaid) containing sodium cholate.胆酸的杀精和抗病毒特性：一种含胆酸钠的新型阴道海绵（Protectaid）的避孕效果。
Hum Reprod. 1993 Jun;8(6):866-9. doi: 10.1093/oxfordjournals.humrep.a138156.
5
Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.环己烯基硫脲和脲类HIV-1逆转录酶非核苷抑制剂具有强效抗人类免疫缺陷病毒（HIV）及使精子失活活性的结构要求。
Biol Reprod. 2002 Dec;67(6):1959-74. doi: 10.1095/biolreprod.102.006478.
6
In vitro inactivation of Chlamydia trachomatis and of a panel of DNA (HSV-2, CMV, adenovirus, BK virus) and RNA (RSV, enterovirus) viruses by the spermicide benzalkonium chloride.杀精剂苯扎氯铵对沙眼衣原体以及一组DNA病毒（单纯疱疹病毒2型、巨细胞病毒、腺病毒、BK病毒）和RNA病毒（呼吸道合胞病毒、肠道病毒）的体外灭活作用。
J Antimicrob Chemother. 2000 Nov;46(5):685-93. doi: 10.1093/jac/46.5.685.
7
Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase.新型氧钒（V）配合物与HIV-1逆转录酶硫脲类非核苷抑制剂的强效双重抗HIV和杀精活性
Biochem Biophys Res Commun. 2003 Mar 7;302(2):253-64. doi: 10.1016/s0006-291x(03)00161-x.
8
Quantification of the in vitro activity of some compounds with spermicidal activity.一些具有杀精活性的化合物的体外活性定量分析。
Contraception. 1992 Dec;46(6):527-36. doi: 10.1016/0010-7824(92)90117-c.
9
Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-human immunodeficiency virus activity.苯乙基-5-溴吡啶基硫脲和二氢烷氧基苄氧基嘧啶的新型衍生物是具有强效抗人类免疫缺陷病毒活性的双功能杀精剂。
Biol Reprod. 1999 Jun;60(6):1419-28. doi: 10.1095/biolreprod60.6.1419.
10
In vitro inactivation of Chlamydia trachomatis and of a panel of DNA (HSV-2, CMV, adenovirus, BK virus) and RNA (RSV, enterovirus) viruses by the spermicide benzalkonium chloride.用杀精剂苯扎氯铵对沙眼衣原体以及一组DNA病毒（单纯疱疹病毒2型、巨细胞病毒、腺病毒、BK病毒）和RNA病毒（呼吸道合胞病毒、肠道病毒）进行体外灭活。
J Antimicrob Chemother. 2001 May;47(5):721-2. doi: 10.1093/oxfordjournals.jac.a002692.
引用本文的文献
1
Effect of betulinic acid and its ionic derivatives on M-MuLV replication.桦木酸及其离子衍生物对 M-MuLV 复制的影响。
Biochem Biophys Res Commun. 2018 Jun 2;500(2):365-369. doi: 10.1016/j.bbrc.2018.04.080. Epub 2018 Apr 21.
2
15 Month follow up of African children following vaginal cleansing with benzalkonium chloride of their HIV infected mothers during late pregnancy and delivery.对在妊娠晚期和分娩期间其感染艾滋病毒的母亲用苯扎氯铵进行阴道清洗的非洲儿童进行15个月的随访。
Sex Transm Infect. 2002 Aug;78(4):267-70. doi: 10.1136/sti.78.4.267.
3
Safety and acceptability of vaginal disinfection with benzalkonium chloride in HIV infected pregnant women in west Africa: ANRS 049b phase II randomized, double blinded placebo controlled trial. DITRAME Study Group.西非感染艾滋病毒的孕妇使用苯扎氯铵进行阴道消毒的安全性和可接受性：ANRS 049b二期随机双盲安慰剂对照试验。DITRAME研究组
Sex Transm Infect. 1999 Dec;75(6):420-5. doi: 10.1136/sti.75.6.420.
4
Bile salts: natural detergents for the prevention of sexually transmitted diseases.胆汁盐：预防性传播疾病的天然去污剂。
Antimicrob Agents Chemother. 1999 Apr;43(4):745-51. doi: 10.1128/AAC.43.4.745.
5
Barrier methods of contraception, spermicides, and sexually transmitted diseases: a review.屏障避孕法、杀精剂与性传播疾病：综述
Genitourin Med. 1994 Dec;70(6):410-7. doi: 10.1136/sti.70.6.410.
6
Lack of evidence for transmission of human immunodeficiency virus through vaginal intercourse.缺乏人类免疫缺陷病毒通过阴道性交传播的证据。
Arch Sex Behav. 1995 Aug;24(4):383-93. doi: 10.1007/BF01541854.
7
Commentary: methods women can use that may prevent sexually transmitted disease, including HIV.评论：女性可采用的预防包括艾滋病毒在内的性传播疾病的方法。
Am J Public Health. 1992 Nov;82(11):1473-8. doi: 10.2105/ajph.82.11.1473.
本文引用的文献
1
2
Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.从艾滋病患者和有患艾滋病风险的人群中频繁检测和分离出细胞病变逆转录病毒（HTLV-III）。
Science. 1984 May 4;224(4648):500-3. doi: 10.1126/science.6200936.
3
Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS.从艾滋病患者和艾滋病前期患者中检测、分离并持续生产细胞病变逆转录病毒（HTLV-III）。
Science. 1984 May 4;224(4648):497-500. doi: 10.1126/science.6200935.
4
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).从一名有获得性免疫缺陷综合征（艾滋病）风险的患者体内分离出一种嗜T淋巴细胞逆转录病毒。
Science. 1983 May 20;220(4599):868-71. doi: 10.1126/science.6189183.
5
Use effectiveness of a spermicidal suppository containing benzalkonium chloride.含苯扎氯铵的杀精栓剂的使用效果。
Contraception. 1986 Oct;34(4):353-62. doi: 10.1016/0010-7824(86)90088-0.
6
[Real and false risks of local contraception: spermicides and the diaphragm].[局部避孕的真实与虚假风险：杀精剂与子宫托]
J Gynecol Obstet Biol Reprod (Paris). 1985;14(3):359-63.
7
Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay.HTLV-III/LAV在携带HTLV-I的细胞MT-2和MT-4中的感染及其在蚀斑试验中的应用。
Science. 1985 Aug 9;229(4713):563-6. doi: 10.1126/science.2992081.
8
In vitro inactivation of HIV-1 by contraceptive sponge containing nonoxynol-9.
Lancet. 1988 Jun 25;1(8600):1456. doi: 10.1016/s0140-6736(88)92261-1.
9
Detection of human immunodeficiency virus by reverse transcriptase assay, antigen capture assay, and radioimmunoassay.通过逆转录酶测定法、抗原捕获测定法和放射免疫测定法检测人类免疫缺陷病毒。
J Clin Microbiol. 1987 Jun;25(6):1122-5. doi: 10.1128/jcm.25.6.1122-1125.1987.
Zotero 插件