美国编码环丙沙星修饰酶的aac(6')-Ib-cr的流行情况。
Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme.
作者信息
Park Chi Hye, Robicsek Ari, Jacoby George A, Sahm Daniel, Hooper David C
机构信息
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114-2696, USA.
出版信息
Antimicrob Agents Chemother. 2006 Nov;50(11):3953-5. doi: 10.1128/AAC.00915-06. Epub 2006 Sep 5.
Abstract
Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes.
摘要
在美国313株对环丙沙星的最低抑菌浓度（MIC）≥0.25μg/ml且对头孢他啶敏感性降低的肠杆菌科细菌中，50.5%的分离株存在aac(6')-Ib，其中28%携带导致低水平环丙沙星耐药的cr变异体。aac(6')-Ib-cr在地理上分布广泛，随时间稳定，在大肠杆菌中最常见，在环丙沙星敏感和耐药菌株中同样普遍，且与qnr基因无关。
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本文引用的文献
1
qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
Antimicrob Agents Chemother. 2006 Aug;50(8):2872-4. doi: 10.1128/AAC.01647-05.
2
qnrB, another plasmid-mediated gene for quinolone resistance.
Antimicrob Agents Chemother. 2006 Apr;50(4):1178-82. doi: 10.1128/AAC.50.4.1178-1182.2006.
3
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase.
Nat Med. 2006 Jan;12(1):83-8. doi: 10.1038/nm1347. Epub 2005 Dec 20.
4
Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae.
J Antimicrob Chemother. 2005 Sep;56(3):463-9. doi: 10.1093/jac/dki245. Epub 2005 Jul 14.
5
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b.
Antimicrob Agents Chemother. 2005 Feb;49(2):801-3. doi: 10.1128/AAC.49.2.801-803.2005.
6
Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States.
Antimicrob Agents Chemother. 2004 Apr;48(4):1295-9. doi: 10.1128/AAC.48.4.1295-1299.2004.
7
Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China.
Antimicrob Agents Chemother. 2003 Jul;47(7):2242-8. doi: 10.1128/AAC.47.7.2242-2248.2003.
8
Mechanism of plasmid-mediated quinolone resistance.
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5638-42. doi: 10.1073/pnas.082092899. Epub 2002 Apr 9.
9
Mechanisms of fluoroquinolone resistance.
Drug Resist Updat. 1999 Feb;2(1):38-55. doi: 10.1054/drup.1998.0068.
10
Mechanisms of action and resistance of older and newer fluoroquinolones.
Clin Infect Dis. 2000 Aug;31 Suppl 2:S24-8. doi: 10.1086/314056.
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