韩国肠杆菌科血液分离株中编码环丙沙星修饰酶的aac(6')-Ib-cr的流行情况。
Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea.
作者信息
Kim Eun Sil, Jeong Jin-Yong, Jun Jae-Bum, Choi Sang-Ho, Lee Sang-Oh, Kim Mi-Na, Woo Jun Hee, Kim Yang Soo
机构信息
Division of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea.
出版信息
Antimicrob Agents Chemother. 2009 Jun;53(6):2643-5. doi: 10.1128/AAC.01534-08. Epub 2009 Mar 16.
Abstract
The aac(6')-Ib gene was detected in 86 of 555 (15.5%) Enterobacteriaceae isolates. Among these 86 aac(6')-Ib-positive isolates, 19 (22.0%) were positive for aac(6')-Ib-cr: 4 of 31 (12.9%) Enterobacter spp., 7 of 13 (53.8%) Escherichia coli isolates, and 8 of 42 (19.0%) Klebsiella pneumoniae isolates. There was a strong association between aac(6')-Ib-cr and OXA-1 and CTX-M-1 group beta-lactamase genes. One aac(6')-Ib-positive K. pneumoniae isolate carried both aac(6')-Ib-cr and qnrS.
摘要
在555株肠杆菌科分离菌株中，检测到86株（15.5%）含有aac(6')-Ib基因。在这86株aac(6')-Ib阳性分离菌株中，19株（22.0%）aac(6')-Ib-cr呈阳性：在31株阴沟肠杆菌中有4株（12.9%），在13株大肠埃希菌中有7株（53.8%），在42株肺炎克雷伯菌中有8株（19.0%）。aac(6')-Ib-cr与OXA-1和CTX-M-1组β-内酰胺酶基因之间存在密切关联。1株aac(6')-Ib阳性肺炎克雷伯菌分离株同时携带aac(6')-Ib-cr和qnrS。
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