Hildebrand J, Bourgeois F, Buyse M, Przedborski S, Goldman S
Service de Neurologie, Université Libre de Bruxelles, Hôpital Erasme, Belgium.
Acta Neurol Scand. 1990 May;81(5):427-30. doi: 10.1111/j.1600-0404.1990.tb00989.x.
The levels of homovanillic acid (HVA), 5-hydroxy indoleacetic acid (5HIAA), and 3-methoxy-4-hydroxy phenylglycol (MHPG) were determined in the cerebrospinal fluid (CSF) of 28 patients with cognitive disorders on Day 1 and Days 8 or 15. During that period all patients were kept hospitalized under strict standard conditions, did not develop any acute CNS lesion, had no changes in their treatment and no acute systemic disease. The mean levels found in the first and second determinations were almost identical for the 3 metabolites; respectively 37.8 ng/ml and 36.3 ng/ml for HVA, 27.8 ng/ml and 27.9 ng/ml for 5HIAA, and 12.9 ng/ml and 12.3 ng/ml for MHPG. Thus, the mean values of these metabolites in CSF are reproducible at least during a 15-day hospitalization. However statistically significant individual changes in metabolite levels were found between the two samples in 82% of patients for HVA, 32% for HIAA and 48% for MHPG. The number of patients required to detect a significant change in the mean levels of each monoamine metabolite has been calculated taking into account the extent of intraindividual variations.
在第1天以及第8天或第15天，对28例认知障碍患者的脑脊液（CSF）中的高香草酸（HVA）、5-羟吲哚乙酸（5HIAA）和3-甲氧基-4-羟基苯乙二醇（MHPG）水平进行了测定。在此期间，所有患者均在严格的标准条件下住院，未出现任何急性中枢神经系统病变，治疗无变化，也无急性全身性疾病。3种代谢物在首次和第二次测定中发现的平均水平几乎相同；HVA分别为37.8 ng/ml和36.3 ng/ml，5HIAA分别为27.8 ng/ml和27.9 ng/ml，MHPG分别为12.9 ng/ml和12.3 ng/ml。因此，这些代谢物在脑脊液中的平均值至少在15天的住院期间是可重复的。然而，在82%的患者中，HVA的两个样本之间发现了代谢物水平的统计学显著个体变化，HIAA为32%，MHPG为48%。在考虑个体内变异程度的情况下，计算了检测每种单胺代谢物平均水平显著变化所需的患者数量。
