Kreth H W, ter Meulen V, Eckert G
Med Microbiol Immunol. 1979 Jan 24;165(4):203-14. doi: 10.1007/BF02152920.
The relationship between HLA determinants on effector and target cells and cell-mediated cytotoxicity was studied using the release of 51Cr from measles virus-infected PHA-blasts. HLA compatibility between effector and target cells was not required if effector lymphocytes were derived from measles seropositive adults, from a patient with SSPE, and from children after live measles vaccination. Cytotoxicity was always abolished after removal of Fc receptor-bearing lymphoid cells. In these donors, the effect is, therefore, probably due to K cells. In contrast, lymphocytes from children with acute measles preferentially killed those virus-infected target cells with which they shared HLA antigens. Selective lytic activity was still observed after elimination of Fc receptor-bearing lymphoid cells. It is suggested that HLA-dependent killer cells represent specific cytotoxic T lymphocytes. These cells seem to be limited to the acute phase of measles.
利用麻疹病毒感染的PHA刺激淋巴细胞释放51Cr，研究了效应细胞和靶细胞上的HLA决定簇与细胞介导的细胞毒性之间的关系。如果效应淋巴细胞来源于麻疹血清反应阳性的成年人、亚急性硬化性全脑炎（SSPE）患者以及接种过麻疹活疫苗的儿童，则效应细胞与靶细胞之间不需要HLA相容性。去除携带Fc受体的淋巴细胞后，细胞毒性总是消失。因此，在这些供体中，这种效应可能是由于K细胞。相比之下，急性麻疹患儿的淋巴细胞优先杀伤那些与它们共享HLA抗原的病毒感染靶细胞。去除携带Fc受体的淋巴细胞后，仍观察到选择性裂解活性。提示HLA依赖的杀伤细胞代表特异性细胞毒性T淋巴细胞。这些细胞似乎仅限于麻疹急性期。
