活动期重度类风湿关节炎患者血清及滑液中的肿瘤坏死因子
Tumour necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritis.
作者信息
Tetta C, Camussi G, Modena V, Di Vittorio C, Baglioni C
机构信息
Laboratorio di Immunopatologia, Università di Torino, Italy.
出版信息
Ann Rheum Dis. 1990 Sep;49(9):665-7. doi: 10.1136/ard.49.9.665.
Abstract
Fifteen serum samples and 29 synovial fluids of patients with rheumatoid arthritis (RA) were examined for the presence of tumour necrosis factor (TNF). The assay for TNF was based on the cytotoxic activity of this cytokine for human melanoma cells in tissue culture. High concentrations of TNF were found in serum samples of patients with severe RA, who had increased erythrocyte sedimentation rate and serum alpha 2 macroglobulin, but decreased haemoglobin and serum iron concentrations. Tumour necrosis factor was also found in the synovial fluid of 16 out of 29 patients. High TNF concentrations were found in fluids with greater than 10(10) leucocytes/l. Tumour necrosis factor was not detected in the serum of normal subjects or in synovial fluid of patients with osteoarthritis. A mediator of inflammation, such as TNF, may contribute to the severity of RA.
摘要
对15份类风湿性关节炎（RA）患者的血清样本和29份滑液进行检测，以确定是否存在肿瘤坏死因子（TNF）。TNF检测基于该细胞因子在组织培养中对人黑素瘤细胞的细胞毒活性。在患有严重RA的患者血清样本中发现高浓度的TNF，这些患者红细胞沉降率和血清α2巨球蛋白升高，但血红蛋白和血清铁浓度降低。29例患者中有16例的滑液中也发现了肿瘤坏死因子。在白细胞计数大于10(10)/l的滑液中发现高浓度的TNF。在正常受试者的血清或骨关节炎患者的滑液中未检测到肿瘤坏死因子。诸如TNF这样的炎症介质可能导致RA病情加重。
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