甲苯二异氰酸酯（TDI）所致呼吸系统疾病的流行病学
Epidemiology of toluene diisocyanate (TDI)-induced respiratory disease.
作者信息
Peters J M, Wegman D H
出版信息
Environ Health Perspect. 1975 Jun;11:97-100. doi: 10.1289/ehp.751197.
Abstract
This paper describes our experience with the respiratory effects of TDI. Five respiratory reactions attributable to TDI are described with supporting evidence. The reactions are sensitization, irritation from overexposure, acute loss of ventilatory capacity, accelerated loss of pulmonary function and induction of a general asthmatic state. Evidence is presented that suggests a safe exposure level.
摘要
本文描述了我们在甲苯二异氰酸酯（TDI）对呼吸系统影响方面的经验。文中描述了五种可归因于TDI的呼吸反应，并提供了支持证据。这些反应包括致敏、过度暴露引起的刺激、通气能力急性丧失、肺功能加速丧失以及诱发全身性哮喘状态。文中还给出了表明安全暴露水平的证据。
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本文引用的文献
1
Evolution of the ventilatory capacity in chronic bronchitis.慢性支气管炎通气能力的演变
Br Med J. 1967 Aug 12;3(5562):392-5. doi: 10.1136/bmj.3.5562.392.
2
3
PREDICTION VALUES FOR SCREENING TESTS OF PULMONARY FUNCTION.肺功能筛查测试的预测值。
Am Rev Respir Dis. 1965 Feb;91:252-61. doi: 10.1164/arrd.1965.91.2.252.
4
STUDIES OF VENTILATORY CAPACITY AND HISTAMINE RESPONSE DURING EXPOSURE TO ISOCYANATE VAPOUR IN POLYURETHANE FOAM MANUFACTURE.聚氨酯泡沫塑料制造过程中异氰酸酯蒸汽暴露期间的通气能力和组胺反应研究
Br J Ind Med. 1963 Jul;20(3):204-9. doi: 10.1136/oem.20.3.204.
5
Toluene di-isocyanate (TDI) toxicity.甲苯二异氰酸酯（TDI）毒性
N Engl J Med. 1963 Feb 14;268:353-7. doi: 10.1056/NEJM196302142680705.
6
The Veterans Administration-Army cooperative study of pulmonary function. I. Clinical spirometry in normal men.退伍军人管理局-陆军肺功能合作研究。I. 正常男性的临床肺量计检查
Am J Med. 1961 Feb;30:243-58. doi: 10.1016/0002-9343(61)90096-1.
7
Ventilation studies on a normal population after a seven-year interval.对正常人群间隔七年后进行的通气研究。
Am Rev Respir Dis. 1966 Jul;94(1):74-8. doi: 10.1164/arrd.1966.94.1.74.
8
Course and prognosis of chronic obstructive lung disease. A prospective study of 200 patients.慢性阻塞性肺疾病的病程与预后。对200例患者的前瞻性研究。
N Engl J Med. 1969 Feb 20;280(8):397-404. doi: 10.1056/NEJM196902202800801.
9
Environmental epidemiology. IV. Chronic respiratory disease in an industrial town: a nine-year follow-up study. Preliminary report.环境流行病学。四、工业城镇中的慢性呼吸道疾病：一项九年随访研究。初步报告。
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10
Acute respiratory effects in workers exposed to low levels of toluene diisocyanate (TDI).接触低水平甲苯二异氰酸酯（TDI）的工人的急性呼吸道影响。
Arch Environ Health. 1968 May;16(5):642-7. doi: 10.1080/00039896.1968.10665121.
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