用于照亮基因靶向脑回路的下一代光学技术。
Next-generation optical technologies for illuminating genetically targeted brain circuits.
作者信息
Deisseroth Karl, Feng Guoping, Majewska Ania K, Miesenböck Gero, Ting Alice, Schnitzer Mark J
机构信息
Department of Bioengineering, Stanford University, Stanford, California 94305, USA.
出版信息
J Neurosci. 2006 Oct 11;26(41):10380-6. doi: 10.1523/JNEUROSCI.3863-06.2006.
Abstract
Emerging technologies from optics, genetics, and bioengineering are being combined for studies of intact neural circuits. The rapid progression of such interdisciplinary "optogenetic" approaches has expanded capabilities for optical imaging and genetic targeting of specific cell types. Here we explore key recent advances that unite optical and genetic approaches, focusing on promising techniques that either allow novel studies of neural dynamics and behavior or provide fresh perspectives on classic model systems.
摘要
来自光学、遗传学和生物工程学的新兴技术正被结合起来用于完整神经回路的研究。这种跨学科“光遗传学”方法的迅速发展扩展了对特定细胞类型进行光学成像和基因靶向的能力。在这里，我们探讨了将光学和基因方法结合起来的近期关键进展，重点关注那些要么能对神经动力学和行为进行全新研究，要么能为经典模型系统提供新视角的有前景的技术。
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