Howley P M, Khoury G, Byrne J C, Takemoto K K, Martin M A
J Virol. 1975 Oct;16(4):959-73. doi: 10.1128/JVI.16.4.959-973.1975.
Two new human papovavirus isolates (JMV and MMV) from the urines of patients with Wiskott-Aldrich syndrome were morphologically and serologically identical to BK virus (BKV). The genomes of these two new isolates were found to be indistinguishable from prototype BKV DNA in a variety of nucleic acid hybridization experiments. Like BKV DNA, JMV and MMV DNAs share approximately 20% of their polynucleotide sequences with simian virus 40 DNA. The genome of JMV was indistinguishable from that of BKV by restriction endonuclease analysis; MMV DNA contained three instead of four R-Hind cleavage sites and one rather than no R-HpaII cleavage sites. Physical maps of the BKV and MMV genomes were constructed using restriction endonucleases, and these maps were oriented to the map of simian virus 40 DNA.
从患有维斯科特-奥尔德里奇综合征患者尿液中分离出的两种新型人乳头多瘤病毒（JMV和MMV）在形态学和血清学上与BK病毒（BKV）相同。在各种核酸杂交实验中，发现这两种新分离株的基因组与原型BKV DNA无法区分。与BKV DNA一样，JMV和MMV DNAs的多核苷酸序列约20%与猴病毒40 DNA相同。通过限制性内切酶分析，JMV的基因组与BKV的基因组无法区分；MMV DNA含有三个而非四个R-Hind切割位点和一个而非没有R-HpaII切割位点。使用限制性内切酶构建了BKV和MMV基因组的物理图谱，并将这些图谱与猴病毒40 DNA的图谱进行了比对。
