Cajal组织学标本中锥体细胞的三维重建及定量研究。
Three-dimensional reconstruction and quantitative study of a pyramidal cell of a Cajal histological preparation.
作者信息
García-López Pablo, García-Marín Virginia, Freire Miguel
机构信息
Museo Cajal, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain.
出版信息
J Neurosci. 2006 Nov 1;26(44):11249-52. doi: 10.1523/JNEUROSCI.3543-06.2006.
Abstract
The year 2006 marks the centenary of the Nobel Prize for Physiology or Medicine awarded to Santiago Ramón y Cajal and Camilo Golgi. We commemorate this centenary with a three-dimensional reconstruction and a quantitative study of a pyramidal cell of a Cajal's histological preparation. This preparation is one of the 4529 histological preparations personally made by Ramón y Cajal and preserved in the Museum Cajal. The three-dimensional reconstruction of the neuron allows visualizing one important discovery of Ramón y Cajal that constitutes an active field of research in present-day neuroscience: dendritic spines.
摘要
2006年是圣地亚哥·拉蒙·伊·卡哈尔（Santiago Ramón y Cajal）和卡米洛·高尔基（Camilo Golgi）荣获诺贝尔生理学或医学奖一百周年。我们通过对卡哈尔组织学标本中的一个锥体细胞进行三维重建和定量研究来纪念这一周年。这个标本是拉蒙·伊·卡哈尔亲手制作并保存在卡哈尔博物馆的4529个组织学标本之一。对该神经元的三维重建使我们能够看到拉蒙·伊·卡哈尔的一项重要发现，这一发现构成了当今神经科学的一个活跃研究领域：树突棘。
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