劳氏肉瘤病毒RNA 5'端的鉴定
Identification of the 5' end of Rous sarcoma virus RNA.
作者信息
Keith J, Fraenkel-Conrat H
出版信息
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3347-50. doi: 10.1073/pnas.72.9.3347.
Abstract
The 5'-terminal triphosphate of the 35S RNA isolated from Rous sarcoma virus is blocked by 7-methylguanosine in 5' linkage with the penultimate nucleoside which is methylated in the 2'-O-ribose position, a type of endgroup found in all animal mRNAs investigated during the past year. The specific nuclease-resistant terminal fragment of RSV RNA has the structure 7mG5'ppp5'GmpCp-. This finding supports the belief that RNA of Rous sarcoma virus represents a (+) strand messenger which may be directly translated upon infection.
摘要
从劳氏肉瘤病毒分离出的35S RNA的5'-末端三磷酸被7-甲基鸟苷以5'连接的方式封闭，该7-甲基鸟苷与倒数第二个核苷相连，倒数第二个核苷在2'-O-核糖位置被甲基化，这是过去一年中研究的所有动物mRNA中发现的一种末端基团类型。劳氏肉瘤病毒RNA的特定抗核酸酶末端片段具有7mG5'ppp5'GmpCp-的结构。这一发现支持了这样一种观点，即劳氏肉瘤病毒的RNA代表一种（+）链信使，在感染时可能会直接被翻译。
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