Atkins G J, Mooney D A, Fahy D A, Ng S H, Sheahan B J
Department of Microbiology, Moyne Institute, Trinity College, Dublin, Ireland.
Neuropathol Appl Neurobiol. 1991 Aug;17(4):299-308. doi: 10.1111/j.1365-2990.1991.tb00727.x.
Rubella virus multiplied to low titre and produced a partial cytopathic effect in rat glial cell cultures. Anti-galactocerebroside staining showed that this cytopathic effect involved the disintegration of oligodendrocytes. A similar effect was produced following infection of myelinating neural cell cultures with rubella virus, but virus multiplication could not be detected in pure neuron cultures. Measles virus was found to multiply and produce a cytopathic effect in primary cultures of both neurons and glial cells. These results are discussed in relation to the ability of measles and rubella viruses to trigger human multiple sclerosis.
风疹病毒在大鼠神经胶质细胞培养物中增殖至低滴度，并产生部分细胞病变效应。抗半乳糖脑苷脂染色显示，这种细胞病变效应涉及少突胶质细胞的解体。用风疹病毒感染有髓神经细胞培养物后也产生了类似的效应，但在纯神经元培养物中未检测到病毒增殖。发现麻疹病毒在神经元和神经胶质细胞的原代培养物中均能增殖并产生细胞病变效应。结合麻疹病毒和风疹病毒引发人类多发性硬化症的能力对这些结果进行了讨论。
