风疹病毒和麻疹病毒在原代大鼠神经细胞培养物中的增殖：与多发性硬化症假定触发机制的相关性。
Multiplication of rubella and measles viruses in primary rat neural cell cultures: relevance to a postulated triggering mechanism for multiple sclerosis.
作者信息
Atkins G J, Mooney D A, Fahy D A, Ng S H, Sheahan B J
机构信息
Department of Microbiology, Moyne Institute, Trinity College, Dublin, Ireland.
出版信息
Neuropathol Appl Neurobiol. 1991 Aug;17(4):299-308. doi: 10.1111/j.1365-2990.1991.tb00727.x.
Abstract
Rubella virus multiplied to low titre and produced a partial cytopathic effect in rat glial cell cultures. Anti-galactocerebroside staining showed that this cytopathic effect involved the disintegration of oligodendrocytes. A similar effect was produced following infection of myelinating neural cell cultures with rubella virus, but virus multiplication could not be detected in pure neuron cultures. Measles virus was found to multiply and produce a cytopathic effect in primary cultures of both neurons and glial cells. These results are discussed in relation to the ability of measles and rubella viruses to trigger human multiple sclerosis.
摘要
风疹病毒在大鼠神经胶质细胞培养物中增殖至低滴度，并产生部分细胞病变效应。抗半乳糖脑苷脂染色显示，这种细胞病变效应涉及少突胶质细胞的解体。用风疹病毒感染有髓神经细胞培养物后也产生了类似的效应，但在纯神经元培养物中未检测到病毒增殖。发现麻疹病毒在神经元和神经胶质细胞的原代培养物中均能增殖并产生细胞病变效应。结合麻疹病毒和风疹病毒引发人类多发性硬化症的能力对这些结果进行了讨论。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 1982 Apr;79(8):2709-13. doi: 10.1073/pnas.79.8.2709.
2
Cells from newborn rat brain established in primary tissue culture will support rubella virus replication.原代组织培养中建立的新生大鼠脑细胞可支持风疹病毒复制。
Can J Microbiol. 1984 Jul;30(7):961-6. doi: 10.1139/m84-150.
3
Induction of experimental allergic encephalomyelitis in genetically resistant strains of mice.在基因抗性小鼠品系中诱导实验性变应性脑脊髓炎
Nature. 1980 Oct 9;287(5782):551-2. doi: 10.1038/287551a0.
4
Genes of the major histocompatibility complex of the mouse.小鼠主要组织相容性复合体的基因
Annu Rev Immunol. 1983;1:529-68. doi: 10.1146/annurev.iy.01.040183.002525.
5
Immunocytochemical demonstration of glial-neuronal interactions and myelinogenesis in subcultures of rat brain cells.大鼠脑细胞亚培养物中神经胶质细胞与神经元相互作用及髓鞘形成的免疫细胞化学证明
J Neuroimmunol. 1985 Aug;9(3-4):159-77. doi: 10.1016/s0165-5728(85)80016-3.
6
Infection of cultured early mouse embryos with Semliki Forest and rubella viruses.用辛德毕斯病毒和风疹病毒感染培养的早期小鼠胚胎。
J Gen Virol. 1986 Jun;67 ( Pt 6):1091-8. doi: 10.1099/0022-1317-67-6-1091.
7
Molecular mimicry and autoimmune disease.分子模拟与自身免疫性疾病。
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8
9
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