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白血病抑制因子的子宫表达与胚泡着床的开始时间一致。

Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation.

作者信息

Bhatt H, Brunet L J, Stewart C L

机构信息

Department of Cell and Developmental Biology, Roche Research Center, Nutley, NJ 07110.

出版信息

Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11408-12. doi: 10.1073/pnas.88.24.11408.

DOI:10.1073/pnas.88.24.11408
PMID:1722331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC53144/
Abstract

We have analyzed the expression of the cytokine leukemia inhibitory factor (LIF) during embryogenesis and in tissues of neonatal and adult mice. The site of the most abundant LIF expression is the uterine endometrial glands, specifically on day 4 of pregnancy. Analysis of LIF expression in pseudopregnant mice and in females undergoing delayed implantation showed that it is under maternal control and that its expression coincides with blastocyst formation and always precedes implantation. These results suggest that a principal function of LIF in vivo may be to regulate the growth and to initiate implantation of blastocysts.

摘要

我们分析了细胞因子白血病抑制因子（LIF）在胚胎发育过程中以及新生和成年小鼠组织中的表达情况。LIF表达最丰富的部位是子宫内膜腺，特别是在妊娠第4天。对假孕小鼠和经历延迟着床的雌性小鼠中LIF表达的分析表明，它受母体控制，其表达与胚泡形成同时发生，并且总是先于着床。这些结果表明，LIF在体内的主要功能可能是调节胚泡的生长并启动着床。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f2/53144/128f386970f0/pnas01074-0440-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f2/53144/554888024471/pnas01074-0438-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f2/53144/ecc8ef539cfe/pnas01074-0438-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f2/53144/b6fed82af384/pnas01074-0439-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f2/53144/128f386970f0/pnas01074-0440-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f2/53144/554888024471/pnas01074-0438-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f2/53144/ecc8ef539cfe/pnas01074-0438-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f2/53144/b6fed82af384/pnas01074-0439-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57f2/53144/128f386970f0/pnas01074-0440-a.jpg

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