Medizinische Universität zu Lübeck, Institut für Biologie, D-2400 Lübeck, Federal Republic of Germany.
Genetics. 1987 Mar;115(3):493-8. doi: 10.1093/genetics/115.3.493.
Bkm sequences, originally isolated from snake satellite DNA, are a component of eukaryote genomes with a preferential location on sex chromosomes. In the Ephestia genome, owing to the presence of only a few Bkm-positive BamHI restriction fragments and to extensive restriction fragment length polymorphisms between and within inbred strains, a genetic crossbreeding analysis was feasible. No sex linkage of Bkm was detected. Instead-depending on the strain-two or three autosomal Bkm DNA loci were identified. All three loci were located on different chromosomes. Fragment length and transmission of fragments was stable in some crosses. In others, changes in fragment length or loss of the Bkm component were observed, probably depending on the source strain of the fragment. The anomalous genetic behaviour is best accounted for by the assumption that Bkm sequences are included in mobile genetic elements.
Bkm 序列最初从蛇卫星 DNA 中分离出来，是真核基因组的一个组成部分，在性染色体上具有优先位置。在 Ephestia 基因组中，由于只有少数 Bkm 阳性 BamHI 限制片段，以及在近交系之间和之内存在广泛的限制片段长度多态性，因此可以进行遗传杂交分析。没有检测到 Bkm 的性连锁。相反，取决于品系，鉴定出两个或三个常染色体 Bkm DNA 基因座。这三个基因座位于不同的染色体上。在某些杂交中，片段长度和片段的传递是稳定的，而在其他杂交中，观察到片段长度的变化或 Bkm 成分的丢失，这可能取决于片段的来源品系。Bkm 序列包含在可移动遗传元件中的假设可以最好地解释这种异常的遗传行为。
