Li Haitao, Leung Christopher Kai Shun, Cheung Carol Yim Lui, Wong Lee, Pang Chi Pui, Weinreb Robert Neal, Lam Dennis Shun Chiu
Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong
Br J Ophthalmol. 2007 Nov;91(11):1490-2. doi: 10.1136/bjo.2007.118901. Epub 2007 May 2.
To evaluate the repeatability and reproducibility of anterior chamber angle measurement obtained by anterior segment optical coherence tomography.
Twenty-five normal subjects were invited for anterior chamber angle imaging with an anterior segment optical coherence tomography (OCT) on one randomly selected eye in three separate visits within a week. Each eye was imaged three times under room light (light intensity = 368 lux) and three times in the dark during the first visit. In the subsequent visits, each eye was imaged once in the light and once in the dark. The angle opening distance (AOD 500) and the trabecular-iris angle (TIA 500) were measured by a single observer. Only the nasal angle was analysed. Intrasession and intersession within-subject standard deviation (Sw), precision (1.96xSw), coefficient of variation (CVw) (100xSw/overall mean), and intraclass correlation coefficient (ICC) were calculated to evaluate repeatability and reproducibility.
For intrasession repeatability, the Sw, precision, CVw and ICC of AOD/TIA were 45 microm/2.4 degrees , 88 microm/4.7 degrees , 5.8%/4.8% and 0.97/0.95 in the light; and 45 microm/2.1 degrees , 88 microm/4.2 degrees , 7.0%/5.0% and 0.98/0.97 in the dark. For intersession reproducibility, the Sw, precision, CVw and ICC of AOD/TIA were 79 microm/3.5 degrees , 155 microm/6.8 degrees , 10.0%/7.0%, 0.91/0.89 in the light; and 64 microm/3.4 degrees , 124 microm/6.6 degrees , 9.9%/7.8% and 0.95/0.92 in the dark.
The anterior segment OCT demonstrated reliable anterior chamber angle measurement in different lighting conditions with good repeatability and reproducibility.
评估眼前节光学相干断层扫描测量前房角的可重复性和再现性。
邀请25名正常受试者，在一周内分三次单独就诊，对其一只随机选择的眼睛进行眼前节光学相干断层扫描（OCT）前房角成像。在第一次就诊时，每只眼睛在室内光（光强度 = 368勒克斯）下成像三次，在黑暗中成像三次。在随后的就诊中，每只眼睛在光照下成像一次，在黑暗中成像一次。由一名观察者测量房角开放距离（AOD 500）和小梁 - 虹膜角（TIA 500）。仅分析鼻侧房角。计算受试者内会话间和会话内的标准差（Sw）、精密度（1.96×Sw）、变异系数（CVw）（100×Sw/总体均值）和组内相关系数（ICC），以评估可重复性和再现性。
对于会话内可重复性，在光照下，AOD/TIA的Sw、精密度、CVw和ICC分别为45微米/2.4度、88微米/4.7度、5.8%/4.8%和0.97/0.95；在黑暗中分别为45微米/2.1度、88微米/4.2度、7.0%/5.0%和0.98/0.97。对于会话间再现性，在光照下，AOD/TIA的Sw、精密度、CVw和ICC分别为79微米/3.5度、155微米/6.8度、10.0%/7.0%、0.91/0.89；在黑暗中分别为64微米/3.4度、124微米/6.6度、9.9%/7.8%和0.95/0.92。
眼前节OCT在前房角测量中在不同光照条件下显示出可靠的可重复性和再现性。
