Avantaggiato Giuseppina, Havenaar Robert, Visconti Angelo
CNR Institute of Sciences of Food Production (ISPA), Via Amendola122/O, I-70126 Bari, Italy.
J Agric Food Chem. 2007 Jun 13;55(12):4810-9. doi: 10.1021/jf0702803. Epub 2007 May 19.
A laboratory model, set to simulate the in vivo conditions of the porcine gastrointestinal tract, was used to study the small intestinal absorption of several mycotoxins and the effectiveness of Standard Q/FIS (a carbon/aluminosilicate-based product) in reducing mycotoxin absorption when added to multitoxin-contaminated diets. Mycotoxins were quickly absorbed in the proximal part of the small intestine at levels of 105 and 89% for fumonisins B1 and B2, respectively, 87% for ochratoxin A, 74% for deoxynivalenol, 44% for aflatoxin B1, and 25% for zearalenone. Addition of Standard Q/FIS to the diet (up to 2%, w/w) significantly reduced mycotoxin absorption, in a dose-dependent manner, up to 88% for aflatoxin B1, 44% for zearalenone, and 29% for the fumonisins and ochratoxin. Standard Q/FIS was ineffective in reducing deoxynivalenol uptake. These findings suggest that Standard Q/FIS can be used as a multitoxin adsorbent material to prevent the individual and combined adverse effects of mycotoxins in animals.
使用一个设定为模拟猪胃肠道体内条件的实验室模型，来研究几种霉菌毒素的小肠吸收情况，以及标准Q/FIS（一种基于碳/铝硅酸盐的产品）添加到受多种毒素污染的日粮中时在减少霉菌毒素吸收方面的有效性。伏马毒素B1和B2在小肠近端的吸收很快，吸收率分别为105%和89%，赭曲霉毒素A为87%，脱氧雪腐镰刀菌烯醇为74%，黄曲霉毒素B1为44%，玉米赤霉烯酮为25%。在日粮中添加标准Q/FIS（最高2%，w/w）可显著降低霉菌毒素的吸收，呈剂量依赖性，黄曲霉毒素B1最高可降低88%，玉米赤霉烯酮降低44%，伏马毒素和赭曲霉毒素降低29%。标准Q/FIS在降低脱氧雪腐镰刀菌烯醇的吸收方面无效。这些发现表明，标准Q/FIS可作为一种多毒素吸附材料，用于预防动物体内霉菌毒素的单一和联合不良影响。
