Collum L M, Logan P, Ravenscroft T
Br J Ophthalmol. 1983 Feb;67(2):115-8. doi: 10.1136/bjo.67.2.115.
Forty patients with disciform keratitis were randomly assigned to double-blind treatment with 3% acyclovir and 0.01% betamethasone drops or acyclovir and matching placebo. All patients who received the combination healed in a median time of 21 days, while 11 of 19 patients who received acyclovir alone were withdrawn because their condition remained static or worsened (p less than 0.001). The combination therapy produced a faster rate of healing (p = 0.004); other clinical parameters also improved more favourably in the combination treatment group. Three patients had mild transient punctate keratopathy, but no serious adverse effects were seen despite treatment for a median duration of 28 days in the acyclovir group and 38 days in the combined therapy group. A combination of acyclovir and dilute steroid drops is effective in the management of disciform keratitis.
40例盘状角膜炎患者被随机分配接受双盲治疗，分别使用3%阿昔洛韦和0.01%倍他米松滴眼液，或阿昔洛韦与匹配的安慰剂。所有接受联合治疗的患者愈合的中位时间为21天，而19例单独接受阿昔洛韦治疗的患者中有11例因病情无改善或恶化而退出研究（p<0.001）。联合治疗的愈合速度更快（p=0.004）；联合治疗组的其他临床参数改善也更明显。3例患者出现轻度短暂性点状角膜病变，但在阿昔洛韦组中位治疗28天、联合治疗组中位治疗38天的情况下，未观察到严重不良反应。阿昔洛韦与稀释的类固醇滴眼液联合应用对盘状角膜炎的治疗有效。
