Sobala G M, Crabtree J E, Dixon M F, Schorah C J, Taylor J D, Rathbone B J, Heatley R V, Axon A T
Gastroenterology Unit, General Infirmary, Leeds.
Gut. 1991 Nov;32(11):1415-8. doi: 10.1136/gut.32.11.1415.
The symptomatology of a case of acute infection with Helicobacter pylori is described, together with the accompanying changes in gastric mucosal histology, local and systemic humoral immune response, and gastric ascorbic acid concentration. The patient was an endoscopist, previously negative for the carbon-14 urea breath test, who had a week of epigastric pain and then became asymptomatic. H pylori was detected by culture of antral biopsy specimens and was still present after 74 days. Five days after infection the histological findings showed acute neutrophilic gastritis; by day 74 changes of chronic gastritis were evident. The patient seroconverted by IgG enzyme linked immunosorbent assay by day 74, but a mucosal IgM and IgA response was evident as early as day 14. Infection was accompanied by a transient hypochlorhydria but a sustained fall in gastric juice ascorbic acid concentration.
本文描述了一例幽门螺杆菌急性感染患者的症状，以及胃黏膜组织学、局部和全身体液免疫反应及胃内维生素C浓度的伴随变化。该患者为内镜医师，之前碳-14尿素呼气试验呈阴性，出现上腹部疼痛一周后症状消失。通过胃窦活检标本培养检测到幽门螺杆菌，且74天后仍存在。感染后5天组织学检查显示急性嗜中性胃炎；至第74天，慢性胃炎变化明显。到第74天，患者通过IgG酶联免疫吸附测定法发生血清转化，但早在第14天黏膜IgM和IgA反应就很明显。感染伴有短暂的胃酸过少，但胃液中维生素C浓度持续下降。
