Koncki Robert
University of Warsaw, Department of Chemistry, Pasteura 1, 02-093 Warsaw, Poland.
Anal Chim Acta. 2007 Sep 5;599(1):7-15. doi: 10.1016/j.aca.2007.08.003. Epub 2007 Aug 6.
A large variety of potentiometric biosensors is developed using biocatalytic and bioaffinity-based biosensing schemes. However, only few of them could be applied for the biomedical analysis. The most promising are those for the detection of main products of protein metabolism, namely urea and creatinine. A novel group of potentiometric biosensors is constituted by bioaffinity-based devices that could be used for immunoassays or genoanalysis. This paper reviews the recent trends in these fields as well as discusses advantages, limitations and pitfalls of the developed biosensors. Some potentiometric biosensors useful for real biomedical analysis are reported in detail.
利用基于生物催化和生物亲和的生物传感方案开发了各种各样的电位型生物传感器。然而，其中只有少数可用于生物医学分析。最有前景的是那些用于检测蛋白质代谢主要产物，即尿素和肌酐的传感器。基于生物亲和的装置构成了一组新型的电位型生物传感器，可用于免疫测定或基因分析。本文综述了这些领域的最新趋势，并讨论了已开发生物传感器的优点、局限性和缺陷。详细报道了一些可用于实际生物医学分析的电位型生物传感器。
